What Causes ALS? - Page 2

By Stephanie Watson @WatsonWriter
November 10, 2017

The genetic link to ALS

About 5 to 10 percent of people with ALS have family members with the disease. This inherited form of the disease is called familial ALS, and it stems from gene mutations that pass down through generations. Only one parent needs to have the mutated gene for his or her child to inherit it.

The gene associated with 30 to 40 percent of familial ALS cases is called C9orf72. It codes for the production of a protein, found in a part of neurons (nerve cells), that sends and receives signals to and from other nerve cells. The same genetic mutation has been associated with frontotemporal dementia (FTD) — a group of related dementias that impair mental function, personality, and motor skills.

A smaller number of inherited ALS cases are caused by mutations to the SOD1, TARDBP, and FUS genes. All of the genes associated with ALS are essential to the health of motor neurons. Damage to these nerve cells leads to muscle weakness and other amyotrophic lateral sclerosis symptoms.


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March 16, 2020

Reviewed By:  

Christopher Nystuen, MD, MBA