Helicobacter Pylori

January 16, 2018

H. pylori (Helicobacter pylori, pronounced Hel-ee-koh-BAK-ter Pie-LORE-ee) is a type of bacteria that infects your stomach.

It can damage the tissue in your stomach and the first part of your small intestine (the duodenum). This can cause redness and soreness (inflammation). In some cases it can also cause painful sores called peptic ulcers in your upper digestive tract.

H. pylori is common. Many people have it. Most people who have it won’t get ulcers or show any symptoms. But it is a main cause of ulcers.

H. pylori attacks the lining that protects your stomach. The bacteria makes an enzyme called urease. This enzyme makes your stomach acids less acidic (neutralizes them). This weakens your stomach’s lining.

Your stomach cells then have greater risk of being hurt by acid and pepsin, strong digestive fluids. That can lead to sores or ulcers in your stomach or duodenum.

The H. pylori bacteria can also stick to stomach cells. Your stomach can’t protect itself very well. The area gets red and swollen (inflamed).

H. pylori can also get the stomach to make more acid. Health experts don’t fully understand how.

Health experts don’t know for sure how H. pylori infection is spread. They believe the germs can be passed from person to person by mouth, such as by kissing.

It may also be passed by having contact with vomit or stool. This may happen if you:

  • Eat food that was not cleaned or cooked in a safe way
  • Drink water that is infected with the bacteria

You may be at greater risk for H. pylori infection because of:

  • Your age. Over half the people in the U.S. with the bacteria are over 50 years old.
  • Your race or ethnicity. Almost half of all African Americans have the bacteria. For people who come to the U.S. from developing countries, at least 50% of Latinos and 50% of people from Eastern Europe have H. pylori.

Most people first get the bacteria when they are children, but adults can get it too.

Most people have the bacteria for years without knowing it because they don’t have any symptoms. Experts don’t know why.

You may have redness and swelling (inflammation) in your stomach lining. This is called gastritis.  

You may get sores or peptic ulcers in your stomach or the first part of your small intestine (duodenum). Ulcer symptoms may include belly or abdominal pain, which can:

  • Be a dull pain that doesn’t go away
  • Happen 2 to 3 hours after you eat
  • Come and go for several days or weeks
  • Happen in the middle of the night when your stomach is empty
  • Go away when you eat or take medicines that reduce your stomach acid level (antacids)

Other symptoms of an ulcer may include:

  • Weight loss
  • Not feeling hungry
  • Swelling or bloating
  • Burping
  • Having an upset stomach or nausea
  • Vomiting

The symptoms of ulcers may look like other health problems. Always see your healthcare provider to be sure.

Your healthcare provider will look at your past health and give you a physical exam. He or she may also use other tests, including:

  • Blood tests. These check for infection-fighting cells (antibodies) that mean you have the bacteria.
  • Stool culture. This looks for any abnormal bacteria in your digestive tract that may cause diarrhea and other problems. A small stool sample is collected and sent to a lab. In 2 or 3 days, the test will show if you have any abnormal bacteria.
  • Breath tests. These can check if there is any carbon after you swallow a urea pill that has carbon molecules. If carbon is found that means that H. pylori has made the enzyme ureaseThis enzyme makes your stomach acids less acidic (neutralizes them). It weakens your stomach’s mucous lining.
  • Upper endoscopy, also called EGD (esophagogastroduodenoscopy). This test looks at the lining of your food pipe (esophagus), stomach, and duodenum (the first part of your small intestine). It uses a thin, lighted tube or endoscope. The tube has a camera at one end. The tube is put into your mouth and throat. Then it goes down into your esophagus, stomach, and duodenum. Your healthcare provider can see the inside of these organs. A small tissue sample (biopsy) is taken if needed. The tissue sample can show if you have the enzyme urease. It can also check the bacteria that is there.

Your healthcare provider will create a care plan for you based on:

  • Your age, overall health, and past health
  • How serious your case is
  • How well you handle certain medicines, treatments, or therapies
  • If your condition is expected to get worse
  • What you would like to do

Your healthcare provider may have you take medicine that kills bacteria (antibiotics).

Other medicines may include:

  • H2-blockers. These are used to reduce the amount of acid in your stomach by blocking the hormone histamine. Histamine helps to make acid.
  • Proton pump inhibitors. These help to keep your stomach from making acid. They do this by stopping the stomach's acid pump from working.
  • Stomach-lining protectors. These medicines protect your stomach lining from acid and help kill bacteria.

If you are infected with the bacteria you can get a painful sore called a peptic ulcer. These sores form in your upper digestive tract.

A very bad ulcer can wear away your stomach lining. It can also cause problems such as:

  • Bleeding when a blood vessel is worn away
  • A hole or perforation in your stomach wall
  • Blockage when the ulcer is in a spot that blocks food from leaving your stomach

H. pylori can also lead to stomach cancer.

Health experts don’t know for sure how the bacteria passes from person to person. But having good health habits (hygiene) can help keep you safe. These habits include:

  • Washing your hands with soap and water. It is very important to do this after using the bathroom and before eating.
  • Making sure all food you eat has been cleaned and cooked safely
  • Making sure that your drinking water is safe and clean
Once you know for sure that you have H. pylori, follow up with your healthcare provider. He or she will do some tests to make sure the bacteria has been removed.Call your healthcare provider if your symptoms get worse or you have new symptoms. Call right away if you have symptoms such as bloody vomit, blood in your stools, or black, tarry-looking stools.
  • H. pylori is a type of bacteria that infects your stomach.
  • It attacks your stomach and the first part of your small intestine (duodenum). This can cause redness and swelling (inflammation).
  • Many people with the bacteria won’t have any symptoms.
  • It can cause open sores called peptic ulcers in your upper digestive tract.
  • It can cause stomach cancer.
  • It may be passed or spread from person to person by mouth, such as by kissing. It may also be passed by direct contact with vomit or stool.
  • Having good health habits (hygiene) can help protect you.
Tips to help you get the most from a visit to your healthcare provider:
  • Before your visit, write down questions you want answered.
  • Bring someone with you to help you ask questions and remember what your provider tells you.
  • At the visit, write down the names of new medicines, treatments, or tests, and any new instructions your provider gives you.
  • If you have a follow-up appointment, write down the date, time, and purpose for that visit.
  • Know how you can contact your provider if you have questions.


January 16, 2018


Guideline on the Management of Helicobacter pylori Infection. Chey William D. American Journal of Gastroenterology. 2007:1808–1825.

Reviewed By:  

Lehrer, Jenifer, MD,Brown, Kim, APRN