Radionuclide Angiogram, Resting and Exercise

Radionuclide Angiogram, Resting and Exercise

January 16, 2018

A resting and exercise radionuclide angiogram (RNA) is a type of nuclear medicine test. This means that a tiny amount of a radioactive substance, called a tracer, is used to help show the tissue under study. In this test, doctors study the heart's chambers in motion. This test can tell the doctor how well the heart pumps and how much blood it pumps with each heartbeat (called the ejection fraction) both during exercise and at rest.

Your doctor injects a radioactive tracer (usually technetium) into an arm vein to "tag" blood cells so he or she can track their progress through the heart with a scanner. A special camera (called a gamma camera) then records the heart muscle at work, like a movie. Your doctor can match these recordings with the electrocardiogram (ECG), a recording of the heart's electrical activity.

An RNA test with rest and exercise is done so the doctor can assess the heart's function during exercise and compare it to how well the heart works at rest. If the heart muscle does not move in a normal way, or not enough blood is pumped out by the heart, it may be a sign of one or more of the following:

  • Injury to the heart muscle, possibly as a result of decreased blood flow to heart muscle due to clogged heart arteries
  • An enlargement of one or more of the heart's chambers
  • Aneurysm (a weak area in the heart muscle)
  • Toxic effects of certain medicines
  • Heart failure

Reasons for your doctor to request a resting and exercise radionuclide angiogram (RNA) include:

  • Chest pain
  • Shortness of breath
  • Dizziness
  • Fatigue (extreme tiredness)

If a screening exam (such as an electrocardiogram or ECG) suggests some type of heart disease that needs to be explored further, a resting and exercise RNA may be done.

There may be other reasons for your doctor to recommend resting and exercise RNA.

The amount of the radioactive tracer your doctor injects into your vein for the test is very small. So, there is no need for precautions against radiation exposure.

The injection of the radioactive tracer may cause some slight discomfort. Allergic reactions to the tracer are rare.

If you are pregnant or think you could be, tell your healthcare provider. There is risk of injury to the fetus from this test. Radiation exposure during pregnancy may lead to birth defects. If you are lactating, or breastfeeding, tell your healthcare provider due to the risk of contaminating breast milk with the radionuclide.

There may be other risks depending on your specific medical condition. Be sure to discuss any concerns with your doctor before the test.

Certain factors may interfere with or affect the results of this test. These include:

  • Caffeine intake within 48 hours of the procedure
  • Smoking or using any form of tobacco within 48 hours of the procedure
  • Certain heart medicines
  • Your doctor will explain the test and you can ask questions.
  • You will be asked to sign a consent form that gives your permission to do the test. Read the form carefully and ask questions if anything is unclear.
  • You may need to fast (not eat or drink) before the test. Your doctor will give you instructions as to how long you should withhold food and liquids.
  • If you are pregnant or think you could be, tell your doctor. Radiation exposure during pregnancy may lead to birth defects.
  • If you are lactating (breastfeeding), tell your healthcare provider due to the risk of contaminating breast milk with the radioactive tracer.
  • Tell your doctor of all medicines (prescription and over-the-counter), vitamins, herbs, and supplements that you are taking.
  • Tell the technologist or doctor if you are allergic to or sensitive to medicines, local anesthesia, contrast dyes, iodine, or latex.
  • Tell your doctor if you have a pacemaker or any other implanted heart devices.
  • Plan to wear loose, comfortable clothing for the exercise part of the test, as well as a comfortable pair of shoes.
  • Based on your medical condition, your doctor may request other specific preparation.

A resting and exercise radionuclide angiogram (RNA) may be done on an outpatient basis or as part of your stay in a hospital. Steps may vary depending on your condition and your doctor's practices.

Generally, a resting and exercise RNA follows this process:

  1. You will be asked to remove any jewelry or other objects that may interfere with the test.
  2. You may need to change into a hospital gown.
  3. A healthcare professional will start an intravenous (IV) line in your hand or arm.
  4. A nurse will connect you to an ECG machine with leads that stick to your skin and a blood pressure cuff will be placed on your arm.
  5. You will lie flat on a table in the procedure room.
  6. Your doctor will inject the radioactive tracer into the vein to "tag" the red blood cells. You will probably not feel anything when the tracer is given.
  7. As another option, a small amount of blood may be withdrawn from your vein so that it may be tagged with the tracer. The tracer will be added to the blood and will be absorbed into the red blood cells, then the blood will be returned into your vein through the IV.
  8. During the test, it will be very important for you to lie as still as possible, as any movement can affect the quality of the scan.
  9. Your doctor will position the gamma camera over you as you lie on the table and will track the progress of the tagged red blood cells through your heart.
  10. The gamma camera will record images of your heart as it pumps the tagged blood cells through your body.
  11. You may be asked to change positions during the test; however, once you have changed position, you will need to lie still without talking.
  12. After the resting scan is done, you will be asked to exercise on a treadmill or stationary bike. If you notice any discomfort, such as chest pain, dizziness, headache, shortness of breath, or extreme fatigue while exercising,  let the technologist or doctor know right away.
  13. You will exercise until you have reached your target heart rate (determined by the doctor based on your age and physical condition), or until you are unable to continue due to chest pain, leg pain, severe shortness of breath, or severe fatigue (tiredness).
  14. Immediately after exercise, you will lie on the table while your doctor records a second set of images.
  15. Once all the heart images are done, your vital signs (heart rate, blood pressure, and respiration rate) will be monitored for a period.
  16. A healthcare professional will remove the IV line, and you will most likely be able to leave, unless your doctor tells you differently.

Move slowly when getting up from the scanner table to avoid any dizziness or lightheadedness from lying flat for the length of the test.

Drink plenty of fluids and empty your bladder often for 24 to 48 hours after the test to help flush the remaining radioactive tracer from your body.

A nurse will check the IV site for any signs of redness or swelling. If you notice any pain, redness, or swelling at the IV site after you go home, tell your doctor as this may be a sign of infection or other type of reaction.

Your doctor may give you other instructions after the test, depending on your situation.

Before you agree to the test or the procedure make sure you know:

  • The name of the test or procedure
  • The reason you are having the test or procedure
  • What results to expect and what they mean
  • The risks and benefits of the test or procedure
  • What the possible side effects or complications are
  • When and where you are to have the test or procedure
  • Who will do the test or procedure and what that person’s qualifications are
  • What would  happen if you did not have the test or procedure
  • Any alternative tests or procedures to think about
  • When and how will you get the results
  • Who to call after the test or procedure if you have questions or problems
  • How much will you have to pay for the test or procedure


January 16, 2018


Fischbach, Frances Talaska. Multigated Acquisition (MUGU) Imaging: Rest and Stress. A Manual of Laboratory and Diagnostic Tests. 2009;8:698–9., Berman, DS. Stress Thallium-201/Rest Technetium-99m Sequential Dual Isotope High-Speed Myocardial Perfusion Imaging. Journal of American College of Cardiology: Cardiovascular Imaging. 2009;2(3):273–82., Tests to evaluate left ventricular systolic function, Up To Date

Reviewed By:  

Gandelman, Glenn, MD, MPH,Fetterman, Anne, RN, BSN