Free Androgen Index
Does this test have other names?
What is this test?
A free androgen index (FAI) is a ratio figured out after a blood test for testosterone. It's used to see whether you have abnormal androgen levels.
Both men and women make male hormones called androgens, which include testosterone. During puberty, testosterone helps children develop into adults. As you age, levels of this hormone can fall. This causes health problems for both men and women.
A testosterone test is a blood test that measures total testosterone, free testosterone, and a protein called steroid hormone binding globulin (SHBG). A free androgen index measures testosterone in your blood and compares it with the total amount of testosterone and SHBG in your body.
Why do I need this test?
You may need this test if you show signs of abnormal androgen levels, which differ in women and men.
These hormones aid in the development of sex organs and other gender-linked traits. For example, androgens play a role in making the female hormone estrogen. When a woman makes too many androgen hormones, she may develop extra body and facial hair. With too little androgen hormones, a woman may become very tired, lose bone mass, or have little interest in sex.
If you are a woman, you may have this test if you have extra hair on your body or face. It's possible that unusual hair growth stems from an ovarian tumor or a condition called polycystic ovarian syndrome (PCOS). Among other things, PCOS causes your ovaries to make too much testosterone. Other symptoms of PCOS include obesity, an irregular menstrual cycle, and prediabetes or diabetes.
Testosterone helps boys develop male traits, and makes facial hair in men. If an adolescent boy isn't developing normally, certain organs might not be making enough of this hormone. Adult men who don't make enough testosterone may feel weak, lose muscle strength and mass, develop breasts, or lose interest in sex.
What other tests might I have along with this test?
Your healthcare provider may also order these tests:
Follicle-stimulating hormone (FSH) and luteinizing hormone (LH)
If you are a woman, you may also get these tests:
Ferriman-Gallwey scale to measure whether you have an unusual amount of body hair (hirsutism)
24-hour determination of urinary free cortisol for Cushing syndrome, a condition that often causes excessive body hair
Dehydroepiandrosterone sulfate, or DHEA-S, a marker for an adrenal source of androgens
ACTH stimulation of 17-OHP, if your 17-OHP level is not clearly normal
Ovarian ultrasound to find out if you have an ovarian tumor
Adrenal CT scan to check for an adrenal tumor or other abnormalities
What do my test results mean?
Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you.
Test results also vary by age, gender, and overall health. Approximate normal FAI values generally range between 30 and 150 in men. Levels below 30 mean a possible testosterone deficiency. Women generally have FAI values of 7 to 10. Approximate normal ranges of serum testosterone for adults are listed below.
300 to 1,000 nanograms per deciliter (ng/dL)
If you are male and your level of total testosterone falls below 200 ng/dL, you may be diagnosed with hypogonadism. This is an androgen deficiency that causes testosterone levels to drop.
20 to 70 ng/dL
Your hormone levels may be affected by a temporary health condition, such as pregnancy. You may also have results that aren't clear and need to be retested.
How is this test done?
The test is done with a blood sample. A needle is used to draw blood from a vein in your arm or hand.
Does this test pose any risks?
Having a blood test with a needle carries some risks. These include bleeding, infection, bruising, and feeling lightheaded. When the needle pricks your arm or hand, you may feel a slight sting or pain. Afterward, the site may be sore.
What might affect my test results?
If you are pregnant, your ovaries may make too much testosterone as part of a normal pregnancy. Having a tumor or cyst in your ovaries or adrenal gland can also cause your testosterone level to rise.
People with Cushing syndrome may also have higher levels of testosterone.
Certain medicines can affect hormone production, including some steroids and opiates. Let your healthcare provider know about any prescription medicine you take.
How do I get ready for this test?
You don't need to prepare for this test. Be sure your healthcare provider knows about all medicines, herbs, vitamins, and supplements you are taking. This includes medicines that don't need a prescription and any illicit drugs you may use.
December 25, 2017
Clinical features and diagnosis of male hypogonadism. UpToDate., Clinical manifestations of polycystic ovary syndrome in adults. UpToDate, Validity of Serum Testosterone, Free Androgen Index, and Calculated Free Testosterone in Women with Suspected Hyperandrogenism. Kindi A. Oman Medical Journal. 2012, is. 27, pp. 471-74.
Fraser, Marianne, MSN, RN,Haldeman-Englert, Chad, MD