A brain tumor is an abnormal growth of tissue in the brain. The brain is part of the central nervous system (CNS). The CNS also includes the spinal cord. The main parts of the brain are:
- Cerebrum. This is the front of the brain. The cerebrum has two sides, the right and left hemispheres. It controls thoughts, emotions, and speech, and movement. It also helps with understanding information from the senses. This includes seeing, hearing, smelling, touching, and feeling pain.
- Cerebellum. This is the back of the brain. It organizes muscle movement and helps to maintain posture, balance, and equilibrium.
- Brainstem. This is the base of the brain. It includes the midbrain, the pons, and the medulla. It is the part of the brain that connects to the spinal cord. It plays a part in controlling muscles and sensations from the body. Part of the brainstem helps control breathing and the heart beat. Many of the cranial nerves start in the brain stem. The cranial nerves carry messages between different parts of the upper body to the brain. These parts include the muscles in the face and around the eyes.
Brain tumors start in the cells of the brain. They can be either of the below:
- Benign. This kind of tumor doesn’t contain cancer cells. In most cases, once a benign tumor is removed, it doesn’t grow back. Most benign brain tumors don’t grow into nearby tissue. These tumors can cause symptoms depending on their size and location in the brain.
- Malignant. This kind of tumor does contain cancer cells. Malignant brain tumors usually grow fast, and grow into nearby tissue. Malignant brain tumors can spread to other parts of the brain or to the spinal cord, but don’t usually spread to other areas of the body. They may grow back after treatment.
Brain tumors can occur at any age. Brain tumors that occur in infants and children are very different from adult brain tumors.
The most common type of brain tumor is a glioma. Gliomas begin from glial cells, which make up the supportive tissue of the brain. There are different types of glioma:
- Astrocytoma. This type of tumor forms from astrocytes, a type of glial cell. It is the most common brain tumor in children. It is grows most often in the cerebellum.
- Brain stem glioma. This tumor is found in the brain stem. Most brain stem tumors can’t be removed with surgery.
- Oligodendroglioma. This tumor grows in the cells that make the fatty covering of nerve cells called oligodendrocytes. It usually grows slowly. But it usually grows into brain tissue. This makes it very difficult to remove with surgery.
- Ependymoma. This usually grows in the lining of the ventricles that hold cerebrospinal fluid (CSF), or in the spinal cord. In children, they are usually near the cerebellum. They often block the flow of the CSF, the fluid that surrounds the brain and spinal cord. This may cause increased pressure in the skull.
- Optic nerve glioma. This kind of tumor is found in or around the nerves that send messages from the eyes to the brain. It often affects vision. It can also affect hormones since it’s usually at the base of the brain where hormone control is located.
Other types of brain tumors include:
- Embryonal tumors. These tumors are found more often in children than in adults. The most common type in children is the medulloblastoma. This kind of tumor start is found in the cerebellum. They tend to grow and spread quickly, but they can often be treated effectively.
- Craniopharyngioma. This kind of tumor starts near the pituitary gland. It is usually slow growing. But it can cause symptoms if it presses on the pituitary gland or on nearby nerves. This type of tumor is benign.
- Mixed glial and neuronal tumors. These tumors are made up of glial and nerve cells.
- Choroid plexus tumor. This is a rare tumor that starts in the ventricles of the brain. It’s also benign.
- Schwannoma. This kind of tumor starts in myelin-making cells that surround certain nerves. It’s most common in the nerve in the inner ear that helps with balance. If it grows there, the tumor is called a vestibular schwannoma or an acoustic neuroma. This type of tumor is usually benign.
Doctors don’t know why certain children develop a brain tumor. Rarely brain tumors are the result of exposure to radiation, or from a familial cancer syndrome.
Children with certain genetic conditions have an increased risk for tumors of the central nervous system. This includes children with:
- Von Hippel-Lindau disease
- Li-Fraumeni syndrome
- Hereditary retinoblastoma
- Tuberous sclerosis
Children who have had radiation therapy for other cancers of the head are also at an increased risk for a new brain tumor.
Symptoms vary depending on size and location of tumor. Symptoms can occur a bit differently in each child.
Growing tumors may cause increased pressure on the brain in the limited space in the skull. This is called increased intracranial pressure or ICP. This isn’t usually the case in babies, since their skull bones haven’t fully grown together. The pressure on the brain may cause symptoms such as:
- Enlarged head, especially in babies
- Nausea and vomiting
- Personality changes
Symptoms of brain tumors in the cerebrum can include:
- Changes in eyesight or hearing
- Trouble talking
- Weakness or paralysis
- Mood changes, such as feeling depressed
Symptoms of brain tumors in the cerebellum can include:
- Trouble swallowing
- Trouble with eye movement
- Changes in speech
- Clumsy movements of the hands, arms, feet, or legs
- Problems walking (ataxia)
Symptoms of brain tumors in the brainstem can include:
- Problems walking (ataxia)
- Muscle stiffness
- Trouble with eye or other facial movement
- Trouble swallowing
- Double vision
- Hearing loss
The symptoms of a brain tumor can be like other health conditions. Make sure your child sees a healthcare provider for a diagnosis.
Your child's healthcare provider will ask about your child's health history and symptoms. He or she will examine your child. This will include a neurological exam. The exam tests reflexes, muscle strength, eye and mouth movement, and coordination. Your child's healthcare provider may refer your child to a doctor specializing in the nervous system (neurologist or neurosurgeon) or to cancer specialist (oncologist). Your child may have tests such as:
- CT scan. A CT scan uses a series of X-rays and a computer to make detailed pictures of the body.
- MRI. An MRI uses large magnets, radio waves, and a computer to make detailed pictures of the body. Contrast dye may be injected into your child's vein. It helps cancer cells be seen more clearly.
- Lumbar puncture. A special needle is placed into the lower back, into the spinal canal. This is the area around the spinal cord. This is done to check the brain and spinal cord for cancer cells. A small amount of cerebral spinal fluid (CSF) is removed and sent for testing. CSF is the fluid around the brain and spinal cord.
- Positron emission tomography (PET) scan. For this test, a radioactive sugar is injected into the bloodstream. Cancer cells use more sugar than normal cells, so the sugar will collect in cancer cells. A special camera is used to see where the radioactive sugar is in the body. A PET scan can sometimes spot cancer cells in different areas of the body, even when they can’t be seen by other tests. This test is often used in combination with a CT scan. This is called a PET/CT scan.
- Biopsy. Tumor cells are removed and sent to a lab for testing. This is done to determine the type of tumor and how quickly it is likely to grow.
- Blood tests. Blood tests may be done to check for substances that are released by some tumors. These are called tumor markers.
These tests will show where and how much cancer there is in your child's body. These are important things to know when deciding how to best treat the cancer and what outcomes to expect. Some types of cancer use standard staging systems of numbers and letters to note this information and whether the cancer has spread. Brain tumors are not staged this way because they usually don't spread. Instead, when planning treatment and predicting outcomes, your child's doctors will look at things like:
- The exact type of tumor
- The location and size of the tumor
- Whether the cancer has spread to the CSF, spinal cord, more than one part of the brain, or beyond the brain
- How the tumor is affecting your child
- Your child's age
- Whether the tumor can be removed with surgery
The doctor will also consider the grade of the cancer cells. This is a measure of how quickly the cells are likely to grow and spread based on much the cancer cells look like normal cells. High-grade cancer cells look very different from normal cells and are more likely to grow and spread quickly.
Your child's doctor will talk to you about these things and recommend treatment for your child. These can be long and complex discussions. Be sure to ask questions and have the doctor explain things to you in a way you understand so you can make the best decisions for your child.
Since brain tumors in children are not common, it is important to find a healthcare team that has experience and skill in treating children with brain tumors.
Treatment may include one or more of the below:
- Surgery. Surgery is usually the first step in the treatment of brain tumors. The goal is to remove as much of the tumor as possible, while keeping brain function.
- Chemotherapy. These are medicines that kill cancer cells or stop them from growing. They may be given into the vein (IV), injected into tissue, or taken by mouth.
- Targeted therapy. These are medicines that focus on specific parts of cancer cells.
- Radiation therapy. These are high-energy X-rays or other types of radiation. They are used to kill cancer cells or stop them from growing.
- High-dose chemotherapy with a stem cell transplant. Young blood cells (stem cells) are taken from the child or from someone else. This is followed by a large amount of chemotherapy medicine. This causes damage to the bone marrow. After the chemotherapy, the stem cells are replaced.
Other treatments may include:
- Corticosteroids. These treat and prevent swelling in the brain.
- Antiseizure medicine. These treat and prevent seizures.
- Ventriculoperitoneal (VP) shunt. A long tube called a shunt may be placed to remove extra fluid from the inside the brain. This helps control the intracranial pressure.
- Supportive care. Treatment can cause side effects. Medicines and other treatments can be used for pain, fever, infection, and nausea and vomiting.
- Antibiotics. These treat and prevent infections.
- Hormones. Medicines can replace hormones if a tumor affects natural hormone production.
With any cancer, how well a child is expected to recover (prognosis) varies. Keep in mind:
- Getting medical treatment right away is important for the best prognosis.
- Ongoing follow-up care during and after treatment is needed.
- New treatments are being tested to improve outcome and to lessen side effects.
A child may have complications from the tumor or from treatment, such as:
- Damage to the brain or nervous system that causes problems with coordination, muscle strength, speech, or eyesight
- Problems after surgery, such as infection, bleeding, and problems with general anesthesia
- Infection and bleeding from chemotherapy
- Delayed growth and development
- Learning problems
- Problems with reproduction (infertility)
- Return of the cancer
- Growth of other cancers
A child with a brain tumor needs ongoing care. Your child will be seen by oncologists and other healthcare providers to treat any late effects of treatment and to watch for signs or symptoms of the tumor returning. Your child will be checked with imaging tests and other tests. And your child may see other healthcare providers for problems from the tumor or from treatment. For example, your child may see an eye doctor (ophthalmologist) for vision problems.
Your child may need therapy to help with movement and muscle strength. This may be done by physical and occupational therapists. If your child's speech is affected, he or she may need help from a speech therapist. Your child may also need the help of other therapists for learning or emotional problems.
You can help your child manage his or her treatment in many ways. For example:
- Your child may have trouble eating. A dietitian may be able to help.
- Your child may be very tired. He or she will need to balance rest and activity. Encourage your child to get some exercise. This is good for overall health. And it may help to lessen tiredness.
- Get emotional support for your child. Find a counselor or child support group can help.
- Make sure your child attends all follow-up appointments.
Call the healthcare provider if your child has:
- Symptoms that get worse
- New symptoms
- Side effects from treatment
- Brain tumors start in the cells of the brain.
- Brain tumors can grow at any age. Those that grow in infants and children are very different from those in adults.
- The types of brain tumors are based on the cell type and location in the brain.
- Some common symptoms of brain tumors are headache, nausea and vomiting, and trouble with movement.
- Most children are treated with surgery, chemotherapy, and radiation therapy.
- On-going follow-up is important in order to watch for effects of tumors or treatment and the cancer growing back.
Tips to help you get the most from a visit to your child’s healthcare provider:
- Know the reason for the visit and what you want to happen.
- Before your visit, write down questions you want answered.
- At the visit, write down the name of a new diagnosis, and any new medicines, treatments, or tests. Also write down any new instructions your provider gives you for your child.
- Know why a new medicine or treatment is prescribed and how it will help your child. Also know what the side effects are.
- Ask if your child’s condition can be treated in other ways.
- Know why a test or procedure is recommended and what the results could mean.
- Know what to expect if your child does not take the medicine or have the test or procedure.
- If your child has a follow-up appointment, write down the date, time, and purpose for that visit.
- Know how you can contact your child’s provider after office hours. This is important if your child becomes ill and you have questions or need advice.
June 06, 2018
Epidemiology of central nervous system tumors in children. UpToDate., Clinical manifestations and diagnosis of central nervous system tumors in children. UpToDate., Overview of the management of central nervous system tumors in children. UpToDate.
Alteri, Rick, MD,Levy, Adam S, MD,Stump-Sutliff, Kim, RN, MSN, AOCNS