Cancer of Unknown Primary: Surgery

March 21, 2017

Cancer of Unknown Primary: Surgery

During surgery, your healthcare provider removes a tumor or tumors from your body. Most of the time, he or she tries to take out all of the cancer and some of the normal tissue around it. Surgery is usually done for cancer that’s easy to reach. For instance, it may be done for a skin growth or a lymph node that the surgeon can feel with his or her fingers.

When surgery may be an option

Cancer of unknown primary (CUP) usually has already spread by the time it’s found. So, surgery is not normally the first treatment option. It might be considered in some situations. These may include if cancer is found in your lymph nodes and your healthcare provider feels it might have spread there from somewhere nearby. Or surgery may be done for biopsies to diagnose and help find out the extent of a cancer. Surgery may also be done to help relieve symptoms, such as pain or other problems (such as a blocked intestine). 

Types of surgery used for cancer of unknown primary

There are many different ways to use surgery to treat CUP. The type of surgery done depends on where the cancer is and what the goal of the surgery is.

If your healthcare provider suggests surgery, be sure you understand how the surgery will be done. You should also understand the goal of the surgery, and its benefits and risks. 

Potential side effects from surgery for cancer of unknown primary

Like other cancer treatments, surgery can cause side effects. These depend on what kind of surgery you have and where in your body the surgery is done.

Side effects can include the following:

  • Pain at the surgical site (incision)

  • Irritation of your skin where the surgery was done

  • Infection

  • Bleeding, either inside your body or at the incision

  • Blood clots

  • Damage to nearby organs or tissues

Tell your healthcare provider if you have any side effects. There are often ways to treat them. If you have poor health and nutrition, you may have an increased risk for infection. You may also have problems with wound healing.

Getting ready for your surgery

Your healthcare team will talk with you about your surgery options. You may want to bring a family member or close friend with you to checkups. Write down questions you want to ask about your surgery. Make sure to ask about:

  • What type of surgery will be done

  • The goal of surgery

  • If the surgery will change the way your body works. This may happen if an organ is removed.

  • The risks and side effects of the surgery

  • When you can return to your normal activities

  • If the surgery will leave scars and what they will look like

Before surgery, tell your healthcare team if you’re taking any medicines. This includes over-the-counter medicines, vitamins, and other supplements. This is to make sure you’re not taking medicines that could affect the surgery. After you’ve talked about all the details with the surgeon, you’ll sign a consent form that says that the healthcare provider can do the surgery.

You’ll also meet the anesthesiologist. You can ask him or her questions about the anesthesia and how it will affect you. Just before your surgery, you’ll receive anesthesia. This is so you fall asleep and don’t feel pain.

After your surgery

You may have to stay in the hospital for a few days. This depends on the type of surgery you had. For the first few days after surgery, you’re likely to have pain from the incision. Your pain can be controlled with medicine. Talk with your healthcare team about your options for pain relief. Some people don’t want to take pain medicine. But doing so can help your healing. If you don’t control pain well, you may not want to cough or turn over often, for instance. You need to do this as you heal from surgery.

You may have diarrhea. Talk with your healthcare provider, nurse, or a dietitian about what you can eat to help. You may have constipation. This can be caused by pain medicine, from not moving much, or from not eating much. Talk with your healthcare team about getting more fiber or using a stool softener.

You may feel tired or weak for a while. The amount of time it takes to heal from surgery is different for each person.

Recovering at home

When you get home, you may get back to light activity. But you may have to avoid strenuous activity for a while. Your healthcare team will tell you what kinds of activities are safe for you while you heal.

Follow-up care

You may need radiation or chemotherapy after surgery. Your healthcare provider will talk with you about this. He or she will help you make appointments, if needed.

When to call your healthcare provider

Tell your healthcare provider right away if you have any signs of problems after surgery. Symptoms can include:

  • Bleeding

  • Redness, swelling, or fluid leaking from the incision

  • Fever

  • Chills

Be sure you know what other problems to watch for. Know how to contact your healthcare provider after office hours and on weekends.



March 21, 2017


Overview of the Classification and Management of Cancers of Unknown Primary Site, UpToDate

Reviewed By:  

Gersten, Todd, MD,Stump-Sutliff, Kim, RN, MSN, AOCNS