Smoking is the biggest risk factor for bladder cancer. People who smoke are at least 3 to 4 times more likely to get bladder cancer as those who don't.

When you smoke, cancer-causing chemicals called carcinogens harm cells in your bladder. Carcinogens from smoke enter the blood through the lungs. The kidneys filter the blood to remove these carcinogens and send them into the urine. The urine goes to the bladder, where it's stored until you urinate. This causes the carcinogens to build up in the urine. They can harm the cells in your bladder. Over time, these damaged cells may turn into cancer.

The younger you were when you started smoking, and the more you smoke, the higher your risk of getting cancer. Some people think that there’s no reason to quit smoking because the damage has already been done. That's not true. Quitting greatly lowers your risk for cancer. And the longer you don't smoke, the more your risk goes down. So, it's worth the effort to do all you can to stop smoking.

White people are twice as likely to get bladder cancer as African Americans or Hispanic Americans.

Bladder cancer happens much more often in men than in women.

The risk for bladder cancer goes up with age. It's rare in people younger than age 40. Most people with bladder cancer are age 65 or older.

Exposure to certain chemicals and dyes can increase your risk for bladder cancer. But exposure to chemicals at work makes up only a small percentage of bladder cancers. If you work in the dye industry or as a hairdresser or truck driver, you may have been exposed to chemicals that increase your risk for bladder cancer. This may also be true if you work with rubber, textiles, leather, paint, metalwork, or printing. Talk with your employer about risk factors involving chemicals. Make sure you follow the guidelines for working with chemicals safely. If you have questions, call:

• The National Institute for Occupational Safety and Health at 800-CDC-INFO (800-232-4636)

• The Occupational Safety and Health Administration at 800-321-OSHA (800-321-6742)

Urinary tract infections and kidney and bladder stones have been linked to bladder cancer.

Using a urinary catheter for a long time has also been linked to bladder cancer.

Using pioglitazone hydrochloride for more than one year has been linked to bladder cancer. This is a diabetes medicine.

Supplements containing Aristolochia fangchi or aristolochic acid have been linked to bladder cancer. This is an herb used in some weight-loss products.

If you've had bladder cancer in the past, even if it was at an early stage, you have a higher risk of getting it again.

Your risk also goes up if you have a family history of bladder cancer. It also goes up if you have certain inherited genetic problems.

Your risk for bladder cancer may be higher if you’ve had certain chemotherapy medicines or radiation directed at your pelvis to treat another cancer in the past.

High levels of arsenic in drinking water have been linked with a higher risk for bladder cancer.