March 21, 2017


Other name(s):

a-amino-isovaleric acid

Unsubstantiated claims

Please note that this section reports on claims that have not yet been substantiated through scientific studies.

Valine may help treat malnutrition due to drug addiction.

Recommended intake

Amino acids (AAs) are available as individual AAs or in AA combinations. They also come as part of multi-vitamins, proteins, and food supplements. The forms include tablets, fluids, and powders.

Note that by eating enough protein in your diet, you get all of the amino acids you need.

You should take valine supplements with leucine and isoleucine.

There are no conditions that increase how much valine you need.

Side effects, toxicity, and interactions

Using a single amino acid supplement may lead to negative nitrogen balance. This can decrease how efficient your metabolism is. It can also make your kidneys work harder. In children, taking single amino acid supplements may also cause growth problems.

You should not take high doses of individual amino acids for long periods of time.

Women who are pregnant or breastfeeding shouldn’t use valine supplements. You also shouldn’t use them if you have maple syrup urine disease (MSUD). This is a rare, inherited disorder.




March 21, 2017


Branched-Chain Amino Acid Metabolism Disorders. Merck Manuals., Maple Syrup Urine Disease. Patrick, AD. Archives of Disease in Childhood. 1960, pp. 269–272.

Reviewed By:  

Poulson, Brittany, RD, CDE,Wilkins, Joanna, R.D., C.D.