Nomame (Cassia nomame)
Natural Standard Bottom Line Monograph, Copyright © 2013 (www.naturalstandard.com). Commercial distribution prohibited. This monograph is intended for informational purposes only, and should not be interpreted as specific medical advice. You should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.
While some complementary and alternative techniques have been studied scientifically, high-quality data regarding safety, effectiveness, and mechanism of action are limited or controversial for most therapies. Whenever possible, it is recommended that practitioners be licensed by a recognized professional organization that adheres to clearly published standards. In addition, before starting a new technique or engaging a practitioner, it is recommended that patients speak with their primary healthcare provider(s). Potential benefits, risks (including financial costs), and alternatives should be carefully considered. The below monograph is designed to provide historical background and an overview of clinically-oriented research, and neither advocates for or against the use of a particular therapy.
Anthraquinoids, anthraquinones, cássia de empingem (Portuguese - Brazil), Cassia mimosoides spp., Cassia nomame, catechins, Chamaecrista mimosoides L., chichani (Marathi), emodic acid, emodin, emodin glycosides, Fabaceae (family), feather-leaved cassia, fish-bone cassia, five-leaf cassia, glucosides, guaiacol peroxidase, hama cha (Japanese), Japanese tea, kawara-ketumei (Japanese), kita, Leguminosae (family), luteolin, luteolin glucosides, mateloi, mateloi lalahi, mimosoides tea, mountain flat-bean, nemucha (Japanese), nomame, nomame herba, patwa ghas (Hindi), phenols, physcion, sensitiva (Portuguese - Brazil), tea senna, ukellela chedip (Palauan).
Nomame (Cassia nomame) is a medicinal herb native to China that now grows wild in many parts of the world. In folk medicine, nomame is reportedly used to increase urine flow. Hama-cha, a water-based extract of nomame leaves, stems, and pods, is a popular tea in Japan.
Nomame is often an ingredient in weight loss products. However, there is a lack of research on the effects of nomame on body weight and fat breakdown in humans.
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
No available studies qualify for inclusion in the evidence table.
*Key to grades:A: Strong scientific evidence for this use; B: Good scientific evidence for this use; C: Unclear scientific evidence for this use; D: Fair scientific evidence against this use (it may not work); F: Strong scientific evidence against this use (it likely does not work).
The below uses are based on tradition or scientific theories. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious and should be evaluated by a qualified health care professional.
Diabetes, diarrhea, diuretic (increases urine flow), fat burning, gastrointestinal conditions, inflammation, metabolic enhancement (improved burning of calories in food), obesity/weight loss.
The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.
Adults (18 years and older)
There is no proven safe or effective dose for nomame in adults. For weight loss, nomame has been taken by mouth 2-3 times daily before meals.
Children (under 18 years old)
There is no proven safe or effective dose for nomame in children.
The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.
Avoid with known allergy or sensitivity to nomame, its constituents, or plants of the Fabaceae (Leguminosae) family, such as peas, beans, and peanuts.
Side Effects and Warnings
Nomame may cause diarrhea. Use with caution in patients with gastrointestinal conditions or conditions where nutrients are poorly taken up by the digestive system.
Use with caution in those who are taking weight loss supplements or those who are on restricted diets.
Avoid with known allergy or sensitivity to nomame, its constituents, or plants of the Fabaceae (Leguminosae) family.
Avoid in pregnant or breastfeeding women.
Pregnancy and Breastfeeding
Nomame is not recommended in pregnant or breastfeeding women, due to a lack of available scientific evidence.
Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.
Interactions with Drugs
Nomame may interact with anticancer drugs, cholesterol-lowering drugs, laxatives, and weight loss drugs.
Interactions with Herbs and Dietary Supplements
Nomame may interact with anticancer herbs and supplements, beta-carotene, cholesterol-lowering herbs and supplements, fat-soluble vitamins, laxative herbs and supplements, and weight loss herbs and supplements.
This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).
Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Brudnak MA. Weight-loss drugs and supplements: are there safer alternatives? Med Hypotheses 2002;58(1):28-33.View Abstract
Ganguly A, Choudhury R, Mitra SR, et al. Chemical Investigation of Cassia mimosoides. Planta Med 1985;51(6):540.View Abstract
Hatano T, Uebayashi H, Ito H, et al. Phenolic constituents of Cassia seeds and antibacterial effect of some naphthalenes and anthraquinones on methicillin-resistant Staphylococcus aureus. Chem Pharm Bull (Tokyo) 1999;47(8):1121-7.View Abstract
Hatano T, Yamashita A, Hashimoto T, et al. Flavan dimers with lipase inhibitory activity from Cassia nomame. Phytochemistry 1997;46(5):893-900.
Kadowaki S, Naitou K, Takahara Y, et al. Extract of Cassia nomame has effect on the cell cycle of CHO-K1 cells and suppresses chromosome aberrations induced by Mitomycin C. Wa-Kan iyakugaku zasshi 2003;20(4):168-172.
Kim YO, Johnson JD, Lee EJ. Phytotoxicity of Phytolacca americana leaf extracts on the growth, and physiological response of Cassia mimosoides. J Chem Ecol 2005;31(12):2963-74.View Abstract
Kitanaka S, Takido M. Anthraquinoids from Cassia nomame. Journal of Natural Products 1985;48:849.
Konishi T, Naitou K, Kadowaki S, et al. Anti-clastogenic ingredients in Cassia nomame extract. Biofactors 2004;22(1-4):99-102.View Abstract
McCarty MF. Nutraceutical resources for diabetes prevention--an update. Med Hypotheses 2005;64(1):151-8.View Abstract
Shimura S, Tsuzuki W, Itoh Y, et al. Inhibitory effect of tannin fraction from Cassia mimosoides L. var. nomame Makino on lipase activity. Nippon Shokuhin Kogyo Gakkai-Shi 1994;41(8):561-564.
Subramanian S, Nagarajan S. Chemical components of the roots and seeds of Cassia mimosoides. Indian J Pharm 1970;32:70-71.
Subramanian S, Nagarajan S. Chemical examination of the leaves of Cassia mimosoides. Indian J Pharm 1969;31:110-111.
Sugimoto T, Wada Y, Yamamura S, et al. Fluorescence study on the nyctinasty of Cassia mimosoides L. using novel fluorescence-labeled probe compounds. Tetrahedron 2001;57(49):9817-9825.
Ueda M, Nakamura Y. Chemical basis of plant leaf movement. Plant Cell Physiol 2007;48(7):900-7.View Abstract
Yamamoto M, Shimura S, Itoh Y, et al. Anti-obesity effects of lipase inhibitor CT-II, an extract from edible herbs, Nomame Herba, on rats fed a high-fat diet. Int J Obes Relat Metab Disord 2000 Jun;24(6):758-64.View Abstract
Copyright © 2013 Natural Standard (www.naturalstandard.com)
The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
March 22, 2017