March 21, 2017


Other Name(s):

a-amino-b-[4-imidazole]-propionic acid


Histidine may help treat allergies and ulcers. It may also aid in rheumatoid arthritis and anemia. It may also improve sexual function. It’s also said to protect against damage caused by ionizing radiation. This can happen from X-rays.

Recommended intake

Amino acids (AAs) are available as individual AAs or in AA combinations. They also come as part of multi-vitamins, proteins, and food supplements. The forms include tablets, fluids, and powders.

Note that by eating enough protein in your diet, you get all of the amino acids you need.

There are no conditions that increase how much histidine you need.

Side effects and toxicity

Using a single amino acid supplement may lead to negative nitrogen balance. This can decrease how efficient your metabolism is. It can also make your kidneys work harder. In children, taking single amino acid supplements may also cause growth problems.

You should not take high doses of individual amino acids for long periods of time.

Taking too much histidine may cause psychological issues. It may also contribute to mood disorders. In general, single amino acid supplements aren’t recommended for people who eat enough or even less than enough protein.

Women who are pregnant or breastfeeding shouldn’t use histidine supplements.


L-histidine has a molecular formula of C6H9N3O2 and a molecular weight of 155.2.




March 21, 2017


Low Free Serum Histidine Concentration in Rheumatoid Arthritis: A Measure of Disease Activity. Gerber, DA. Journal of Clinical Investigation. 1975, issue 55, pp. 1164–1173.

Reviewed By:  

Poulson, Brittany, RD, CDE,Wilkins, Joanna, R.D., C.D.