Abuta (Cissampelos pareira)
Natural Standard Bottom Line Monograph, Copyright © 2013 (www.naturalstandard.com). Commercial distribution prohibited. This monograph is intended for informational purposes only, and should not be interpreted as specific medical advice. You should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.
While some complementary and alternative techniques have been studied scientifically, high-quality data regarding safety, effectiveness, and mechanism of action are limited or controversial for most therapies. Whenever possible, it is recommended that practitioners be licensed by a recognized professional organization that adheres to clearly published standards. In addition, before starting a new technique or engaging a practitioner, it is recommended that patients speak with their primary healthcare provider(s). Potential benefits, risks (including financial costs), and alternatives should be carefully considered. The below monograph is designed to provide historical background and an overview of clinically-oriented research, and neither advocates for or against the use of a particular therapy.
Abuta fluminum, Abuta grandifolia, Abuta grisebachii, Abuta panurensis, abutua, aristoloche lobee, barbasco, bejuco de cerca, bejuco de raton, butua, false pareira, feuille coeur, gasing-gasing, ice vine, imchich masha, liane patte cheval, Menispermaceae, pareira, pareira brava, patacon, velvetleaf.
Abuta grows in the Amazon basin and other humid, tropical areas of the world. It is known as a "midwife's herb" in South America and is used to treat a variety of women's complaints. In some parts of the world, abuta is used to reduce fever, inflammation, and pain. In the United States, abuta is used mainly for minor reproductive tract conditions such as menstrual cramping.
Abuta may function as an emmenagogue (menstrual flow stimulant). However, there are no human trials that have determined the safety and effectiveness of the abuta plant on the menstrual cycle. Future research is needed before a recommendation can be made.
Documented uses in traditional medicine show that abuta is used as a diuretic (increases urine flow), expectorant (expels phlegm), emmenagogue, and antipyretic (reduces fever). It is also used to prevent abortion, relieve heavy menstrual bleeding, and stop uterine hemorrhages (bleeding). Powdered abuta bark has also used for menstrual complaints.
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
No available studies qualify for inclusion in the evidence table.
*Key to grades:A: Strong scientific evidence for this use; B: Good scientific evidence for this use; C: Unclear scientific evidence for this use; D: Fair scientific evidence against this use (it may not work); F: Strong scientific evidence against this use (it likely does not work).
The below uses are based on tradition or scientific theories. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious and should be evaluated by a qualified health care professional.
Acne, anemia, animal bites, antiparasitic, aphrodisiac, asthma, boils, bronchitis, burns, childbirth, cholera, colds, colic, constipation, convulsions, cough, cystitis (inflammation of the bladder), delirium, dental analgesia (dental pain), diabetes, diarrhea, digestion, diuretic, dropsy (edema), dysentery (severe diarrhea), dyspepsia (upset stomach), expectorant (expels phlegm), eye infections, fertility (in women), fever, hematuria (blood in the urine), hemorrhage (bleeding), hypercholesterolemia (high cholesterol), hypertension (high blood pressure), insecticide, itching, jaundice, kidney stones, laxative, leukorrhea (vaginal discharge), malaria, menstrual flow stimulant, menstrual pain, nephritis, palpitations, pregnancy (pain), rabies, rheumatism, shivering, skin infections (erysipelas), snake bites, sores, stimulant, stomach ache, tonic, toothache, typhoid, venereal diseases, wounds.
The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.
Adults (18 years and older)
Safety and effectiveness have not been proven for any dose. For menstrual complaints, 1-2 grams of powdered abuta bark in tablets or capsules has been used twice daily. Abuta has also been taken as a 4:1 tincture in a dose of 2-4 milliliters twice daily.
Children (younger than 18 years)
There is not enough scientific evidence to safely recommend abuta for use in children.
The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.
Individuals with a known allergy or hypersensitivity to abuta or any component of the formulation should not take abuta.
Side Effects and Warnings
Currently, there is not enough available evidence about the safety of abuta. Use in pregnant women is not advised due to possible abortion-inducing effects, although there is controversy in this area.
Be aware that many plants related to abuta look alike. Some abuta products may be contaminated with these similar plants.
Pregnancy and Breastfeeding
Abuta is not recommended in pregnant or breastfeeding women. Abuta may cause abortion, although there is controversy in this area.
Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.
Interactions with Drugs
Currently, there is a lack of available scientific evidence describing drug interactions with abuta.
Interactions with Herbs and Dietary Supplements
Currently, there is a lack of available scientific evidence describing herb and supplement interactions with abuta.
This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).
Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Ahmad R, Cava MP. Grisabine and grisabutine, new bisbenzylisoquinoline alkaloids from Abuta grisebachii. J Org.Chem 6-24-1977;42(13):2271-2273. View Abstract
Amresh Reddy GD, Rao CV, Shirwaikar A. Ethnomedical value of Cissampelos pareira extract in experimentally induced diarrhoea. Acta Pharm 2004;54(1):27-35. View Abstract
Anwer F, Popli SP, Srivastava RM, et al. Studies in medicinal plants. 3. Protoberberine alkaloids from the roots of Cissampelos pareira Linn. Experientia 10-15-1968;24(10):999. View Abstract
Basu DK. Studies on curariform activity of hayatinin methochloride, an alkaloid of Cissampelos pareira. Jpn J Pharmacol 1970;20(2):246-252. View Abstract
Bhatnagar AK, Popli SP. Chemical examination of the roots of Cissampelos pareira Linn. V. Structure and stereochemistry of hayatidin. Experientia 4-15-1967;23(4):242-243. View Abstract
Cava MP, Saa JM, Lakshmikantham MV, et al. Panurensine and norpanurensine, new bisbenzylisoquinoline alkaloids from Abuta panurensis. J Org.Chem. 9-5-1975;40(18):2647-2649. View Abstract
Ciccia G, Coussio J, Mongelli E. Insecticidal activity against Aedes aegypti larvae of some medicinal South American plants. J Ethnopharmacol 2000;72(1-2):185-189. View Abstract
Fischer DC, Amorim Gualda NC, Bachiega D, et al. In vitro screening for antiplasmodial activity of isoquinoline alkaloids from Brazilian plant species. Acta Trop 2004;92(3):261-266. View Abstract
Galeffi C, Scarpetti P, Marini-Bettolo GB. New curare alkaloids. II. New bisbenzylisoquinoline alkaloids from Abuta grisebachii (Menispermaceae). Farmaco [Sci] 1977;32(12):853-865. View Abstract
Kupchan SM, Patel AC, Fujita E. Tumor inhibitors. VI. Cissampareine, new cytotoxic alkaloid from Cissampelos pareira. Cytotoxicity of bisbenzylisoquinoline alkaloids. J Pharm Sci 1965;54(4):580-583. View Abstract
Morita H, Matsumoto K, Takeya K, et al. Structures and solid state tautomeric forms of two novel antileukemic tropoloisoquinoline alkaloids, pareirubrines A and B, from Cissampelos pareira. Chem Pharm Bull (Tokyo) 1993;41(8):1418-1422. View Abstract
Ramirez I, Carabot A, Melendez P, et al. Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira. Phytochemistry 2003;64(2):645-647. View Abstract
Steele JC, Simmonds MS, Veitch NC, et al. Evaluation of the anti-plasmodial activity of bisbenzylisoquinoline alkaloids from Abuta grandifolia. Planta Med 1999;65(5):413-416. View Abstract
Sur RN, Pradhan SN. Studies on cissampelos alkaloids. I. Action of hayatin derivatives on the central nervous system of cats and dogs. Arch Int Pharmacodyn Ther 11-1-1964;152:106-114. View Abstract
Copyright © 2013 Natural Standard (www.naturalstandard.com)
The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
March 22, 2017