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What is this medicine?
ZIV-AFLIBERCEPT (ziv a FLIB er sept) is a chemotherapy drug. It works by slowing or stopping cancer cell growth. It is used with other medicines to treat certain types of colon cancer.
How should I use this medicine?
This medicine is for infusion into a vein. It is given by a health care professional in a hospital or clinic setting.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
bloody or black, tarry stools
changes in vision
confusion, trouble speaking or understanding
fever or chills, sore throat
red or dark-brown urine
shortness of breath, chest pain, swelling in a leg
spitting up blood or brown material that looks like coffee grounds
sudden numbness or weakness of the face, arm or leg
trouble walking, dizziness, loss of balance or coordination
unusual bruising or bleeding from the eye, gums, or nose
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
loss of appetite
mouth or throat sores or ulcers
unusually weak or tired
What may interact with this medicine?
Interactions are not expected.
What if I miss a dose?
It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.
Where should I keep my medicine?
This drug is given in a hospital or clinic and will not be stored at home.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
high blood pressure
history of stomach bleeding
history of stroke
infection (especially a virus infection such as chickenpox, cold sores, or herpes)
low blood counts, like low white cell, platelet, or red cell counts
an unusual or allergic reaction to ziv-aflibercept, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
What should I watch for while using this medicine?
Your condition will be monitored carefully while you are receiving this medicine.
Before having surgery or dental work, talk to your health care provider to make sure it is ok. This drug can increase the risk of poor healing of your surgical site or wound. You will need to stop this drug for 4 weeks before surgery. After surgery, wait at least 4 weeks before restarting this drug. Make sure the surgical site or wound is healed enough before restarting this drug. Talk to your health care provider if questions.
Do not become pregnant while taking this medicine or for 1 month after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 1 month after stopping it.
This medicine has caused ovarian failure in some women. This medicine may make it more difficult to get pregnant. Talk to your health care professional if you are concerned about your fertility.
This medicine has caused decreased sperm counts in some men. This may make it more difficult to father a child. Talk to your health care professional if you are concerned about your fertility.
Check with your doctor or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine.
You may need blood work done while you are taking this medicine.
Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.
Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.
This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.
October 18, 2020