Toremifene Citrate Oral tablet

What is this medicine?

TOREMIFENE (tore EM i feen) blocks the effects of estrogen. It is used to treat some types of breast cancer.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• blood clots

• high calcium levels

• an unusual or allergic reaction to toremifene, other medicines, foods, dyes, or preservatives

• pregnant or trying to get pregnant

• breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take this medicine with or without food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

• certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole

• cisapride

• dofetilide

• dronedarone

• pimozide

• thioridazine

• ziprasidone

This medicine may also interact with the following medications:

• certain antibiotics like erythromycin

• certain diuretics like hydrochlorothiazide

• certain medicines for seizures like carbamazepine, phenobarbital, phenytoin

• certain medicines that treat or prevent blood clots like warfarin

• female hormones, like estrogens and birth control pills

• other medicines that prolong the QT interval (cause an abnormal heart rhythm)

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. You will need regular pelvic exams, breast exams, and mammograms.

If you have bone tumors, this medicine may cause bone pain and/or high blood calcium. Talk to your doctor about what symptoms are possible and what to do if you have these symptoms.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• bone pain

• breathing problems

• changes in vision

• chest pain

• depression

• pain, redness, swelling in a leg

• swelling of hands, feet

• unusual bruising, bleeding

• vaginal bleeding or discharge

• yellowing of eyes, skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• dizziness

• hot flashes

• loss of appetite

• nausea, vomiting

• sweating

• unusually weak or tired

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from heat and light. Keep container tightly closed. Throw away any unused medicine after the expiration date.