Sonidegib oral capsules
What is this medicine?
SONIDEGIB (soe ni deg ib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat basal cell carcinoma, a type of skin cancer.
How should I use this medicine?
Take this medicine by mouth with a glass of water. Do not cut, crush, or chew this medicine. Take this medicine on an empty stomach, at least 1 hour before or 2 hours after food. Do not take with food. Do not take with grapefruit juice. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
signs and symptoms of muscle injury like dark urine; trouble passing urine or change in the amount of urine; unusually weak or tired; muscle pain or side or back pain
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
changes in taste
loss of appetite
What may interact with this medicine?
This medicine may interact with the following medications:
certain medicines for fungal infections like ketoconazole, itraconazole, fluconazole, posaconazole and voriconazole
certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
stomach acid blockers like cimetidine, famotidine, ranitidine, or omeprazole
St. John's Wort
What if I miss a dose?
If a dose is missed, skip the dose and take the dose the next day at the scheduled time.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
history of a muscle disorder
an unusual or allergic reaction to sonidegib, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
What should I watch for while using this medicine?
This drug may make you feel generally unwell. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.
Do not become pregnant while taking this medicine or for 20 months after stopping it. Women of child-bearing potential will need to have a negative pregnancy test before starting this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. This medicine can cause severe birth defects or death to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 20 months after stopping it.
Men should not father a child while taking this medicine. Men must use a latex condom during sexual contact with a woman while taking this medicine and for 8 months after you stop taking this medicine. A latex condom is needed even if you have had a vasectomy. Contact your doctor right away if your partner becomes pregnant. Do not donate sperm while taking this medicine and for at least 8 months after you stop taking this medicine.
Do not give blood while taking the medicine and for 20 months after completion of treatment to avoid exposing pregnant women to the medicine through the donated blood.
You may need blood work done while you are taking this medicine.
September 30, 2017