Ritonavir oral solution

December 27, 2019

Ritonavir oral solution

What is this medicine?

RITONAVIR (ri TOE na veer) is an antiretroviral medicine. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. This medicine can lower, but not fully prevent, the risk of spreading HIV to others.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with food. Shake well before using. Use a specially marked spoon or dropper to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. You can mix the dose with chocolate milk, Ensure, or Advera to make it taste better. Take the medicine within 1 hour if you mix it with these items. Throw it away if you cannot take it within 1 hour. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your anti-HIV therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the HIV virus resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 1 month old for selected conditions, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • fast, irregular heartbeat

  • feeling faint or lightheaded, falls

  • nausea, vomiting, abdominal pain

  • redness, blistering, peeling or loosening of the skin, including inside the mouth

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • decreased appetite

  • diarrhea

  • dizziness

  • headache

  • increased hunger or thirst

  • increased urination

  • tingling or numbness in the hands or feet or around the mouth

  • unusually weak or tired

  • weight gain around waist, back, or thinning of face, arms, legs

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • alfuzosin

  • apalutamide

  • certain medicines for irregular heart beat like amiodarone, bepridil, dofetilide, dronedarone, flecainide, propafenone, quinidine

  • cobicistat

  • conivaptan

  • eletriptan

  • eliglustat

  • enzalutamide

  • eplerenone

  • ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine

  • flibanserin

  • idelalisib

  • isavuconazonium

  • ivabradine

  • lomitapide

  • lovastatin

  • lurasidone

  • meperidine

  • naloxegol

  • pergolide

  • pimozide

  • ranolazine

  • red yeast rice

  • rifampin

  • silodosin

  • simvastatin

  • St. John's wort

  • terfenadine

  • tinidazole

  • tolvaptan

  • triazolam

  • voriconazole

This medicine may also interact with the following medications:

  • atovaquone

  • bedaquiline

  • bosentan

  • birth control pills, patches, rings, or injections

  • certain medicines for blood pressure, heart disease, irregular heart beat like digoxin, disopyramide, lidocaine, mexiletine, metoprolol, timolol

  • certain medicines for cancer like abemaciclib, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax, vinblastine, vincristine

  • certain medicines for cholesterol like atorvastatin, rosuvastatin

  • certain medicines for depression, anxiety, or psychotic disturbances amitriptyline, bupropion, desipramine, fluoxetine, nefazodone, nortriptyline, paroxetine, perphenazine, quetiapine, risperidone, thioridazine, trazodone

  • certain medicines for erectile dysfunction like avanafil, sildenafil, tadalafil, vardenafil

  • certain medicines for fungal infections like fluconazole, itraconazole, posaconazole

  • certain medicines for seizures like carbamazepine, clonazepam, ethosuximide, divalproex, lamotrigine, phenytoin

  • certain medicines for sleep like buspirone, clorazepate, diazepam, estazolam, flurazepam, zolpidem

  • certain medicines that treat or prevent blood clots like warfarin, rivaroxaban

  • clarithromycin

  • colchicine

  • cyclosporine

  • dronabinol

  • elagolix

  • fostamatinib

  • methamphetamine

  • metronidazole

  • narcotic medicines for pain

  • other antivirals for HIV

  • quinine

  • rifabutin

  • salmeterol

  • simeprevir

  • sirolimus

  • steroid medicines like betamethasone, budesonide, ciclesonide, dexamethasone, fluticasone, methylprednisolone, mometasone, prednisolone, triamcinolone

  • tacrolimus

  • theophylline

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Do not refrigerate. Keep in the original container. Protect from heat and light. Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • diabetes

  • hemophilia

  • high cholesterol or triglycerides

  • liver disease

  • an unusual or allergic reaction to ritonavir, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.

HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV.

Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control. Women who can still have children must use a reliable form of barrier contraception, like a condom or diaphragm.

This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.

Some products may contain alcohol. Ask your pharmacist or healthcare provider if this medicine contains alcohol. Be sure to tell all healthcare providers you are taking this medicine. Certain medicines, like metronidazole and disulfiram, can cause an unpleasant reaction when taken with alcohol. The reaction includes flushing, headache, nausea, vomiting, sweating, and increased thirst. The reaction can last from 30 minutes to several hours.


December 27, 2019