Regorafenib tablets
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Regorafenib tablets
What is this medicine?
REGORAFENIB (RE goe RAF e nib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat colorectal cancer, gastrointestinal stromal tumors (GIST), and liver cancer.
How should I use this medicine?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not take it more often than directed. Take this medicine with food. Do not take with grapefruit juice. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
bloody or black, tarry stools
breathing problems
changes in vision
chest pain or chest tightness
confusion
dizziness
feeling faint or lightheaded
high fever
light-colored stools
nausea, vomiting
red or dark-brown urine
red spots on the skin
right upper belly pain
seizures
severe headache
sores on the hands or feet
spitting up blood or brown material that looks like coffee grounds
stomach pain
unusual bruising or bleeding from the eye, gums, or nose
unusually weak or tired
yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
diarrhea
hoarseness
loss of appetite
sore throat
tiredness
weight loss
What may interact with this medicine?
This medicine may interact with the following:
carbamazepine
irinotecan
itraconazole
ketoconazole
phenobarbital
phenytoin
posaconazole
rifampin
St. John's Wort
telithromycin
voriconazole
warfarin
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Where should I keep my medicine?
Keep out of the reach of children.
Store between 20 and 25 degrees C (68 and 77 degrees F). Keep this medicine in the original container. Throw away any unused medicine 7 weeks after opening the bottle.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
bleeding disorders
heart disease
high blood pressure
liver disease
recent surgery
an unusual or allergic reaction to regorafenib, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
What should I watch for while using this medicine?
This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.
You may need blood work done while you are taking this medicine.
Do not become pregnant while taking this medicine or for 2 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 2 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 2 weeks after stopping it.
Before having surgery, talk to your health care provider to make sure it is ok. This drug can increase the risk of poor healing of your surgical site or wound. You will need to stop this drug for 2 weeks before surgery. After surgery, wait at least 2 weeks before restarting this drug. Make sure the surgical site or wound is healed enough before restarting this drug. Talk to your health care provider if questions.
Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine.
Updated:  
October 18, 2020