Posaconazole injection

November 22, 2020

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Posaconazole injection

What is this medicine?

POSACONAZOLE (POE sa KON a zole) is an antifungal medicine. It is used to prevent certain kinds of fungal or yeast infections.

How should I use this medicine?

This medicine is for infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • dark urine

  • diarrhea and/or vomiting

  • fever

  • irregular heartbeat, chest pain

  • pale stools

  • redness, blistering, peeling or loosening of the skin, including inside the mouth

  • swelling in feet, ankles, legs

  • tingling hands, feet

  • unusual bruising or bleeding

  • unusually weak or tired

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • dizziness

  • headache

  • loss of appetite

  • nausea

  • stomach upset, bloating

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • certain medicines for cholesterol like atorvastatin, lovastatin, simvastatin, lomitapide

  • certain medicines for irregular heart beat like dronedarone, quinidine

  • cisapride

  • ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine

  • ibrutinib

  • lapatinib

  • naloxegol

  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)

  • pimozide

  • sirolimus

  • thioridazine

This medicine may also interact with the following medications:

  • antiviral medicines for HIV or AIDS

  • certain medicines for anxiety or sleep like alprazolam, midazolam, triazolam

  • certain medicines for blood pressure like diltiazem, nifedipine, nicardipine, verapamil

  • certain medicines for cancer like vinblastine, vincristine

  • certain medicines for diabetes like glipizide

  • certain medicines for seizures like phenytoin

  • digoxin

  • dofetilide

  • medicines that lower your chance of fighting infection like cyclosporine, tacrolimus

  • metoclopramide

  • other medicines for fungal infections

  • rifabutin

  • ziprasidone

What if I miss a dose?

This does not apply.

Where should I keep my medicine?

Keep out of the reach of children.

This drug is usually given in a hospital or clinic and will not be stored at home.

In rare cases, this medicine may be given at home. If you are using this medicine at home, you will be instructed on how to store this medicine. Throw away any unused medicine after the expiration date on the label.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • heart disease

  • history of irregular heartbeat

  • history of low levels of calcium, magnesium, or potassium in the blood

  • kidney disease

  • liver disease

  • an unusual or allergic reaction to posaconazole, antifungals, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.


November 22, 2020