What is this medicine?
PERAMPANEL (per AM pa nel) is used to treat certain types of seizures in patients with epilepsy.
How should I use this medicine?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years for selected conditions, precautions do apply.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
fever with rash, swollen lymph nodes, or swelling of the face
suicidal thoughts or other mood changes
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
loss of balance or coordination
What may interact with this medicine?
This medicine may interact with the following medications:
antihistamines for allergy, cough and cold
certain birth control pills containing levonorgestrel
certain medicines for anxiety or sleep
certain medicines for depression like amitriptyline, fluoxetine, sertraline
certain medicines for fungal infections like ketoconazole
certain medicines for seizures like carbamazepine, eslicarbazine, oxcarbazepine, phenobarbital, phenytoin, primidone, topiramate
general anesthetics like halothane, isoflurane, methoxyflurane, propofol
medicines that relax muscles for surgery
narcotic medicines for pain
phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
St. John's wort
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Where should I keep my medicine?
Keep out of the reach of children.
This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law.
This medicine may cause accidental overdose and death if it taken by other adults, children, or pets. Mix any unused medicine with a substance like cat litter or coffee grounds. Then throw the medicine away in a sealed container like a sealed bag or a coffee can with a lid. Do not use the medicine after the expiration date.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F).
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
drug abuse or addiction
history of a drug or alcohol abuse problem
history of depression or bipolar disorder
if you often drink alcohol
suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member
an unusual or allergic reaction to perampanel, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
What should I watch for while using this medicine?
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.
Visit your doctor or healthcare professional for regular checks on your progress. Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.
It is important to take this medicine exactly as directed. When first starting treatment, your dose will need to be adjusted slowly. It may take weeks or months before your dose is stable. You should contact your doctor or healthcare professional if your seizures get worse or if you have any new types of seizures. Do not stop taking this medicine unless instructed by your doctor or healthcare professional. Stopping your medicine suddenly can increase your seizures or their severity.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
Some birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control.
The use of this medicine may increase the chance of suicidal thoughts or actions. Pay special attention to how you are responding while on this medicine. Any worsening of mood, or thoughts of suicide or dying should be reported to your health care professional right away.
July 17, 2018