Paliperidone extended-release injection
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Paliperidone extended-release injection
What is this medicine?
PALIPERIDONE (pal ee PER i done) injection is given by a health care professional. The once-monthly injection (Invega Sustenna) is used for the treatment of schizophrenia or for schizoaffective disorder. The 3-month injection (Invega Trinza) is used for the treatment of schizophrenia.
How should I use this medicine?
This medicine is for injection into a muscle. It is given by a health care professional in a hospital or clinic setting.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
breast enlargement in both males and females
breathing problems
confusion
fast, irregular heartbeat
fever or chills, sore throat
inability to keep still
males: prolonged or painful erection
missed menstrual periods
pain, redness or irritation at site where injected
problems with balance, talking, walking
seizures
signs and symptoms of high blood sugar such as being more thirsty or hungry or having to urinate more than normal. You may also feel very tired or have blurry vision
signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired
signs and symptoms of neuroleptic malignant syndrome like confusion; fast or irregular heartbeat; high fever; increased sweating; stiff muscles
sudden numbness or weakness of the face, arm, or leg
suicidal thoughts or other mood changes
trouble swallowing
uncontrollable movements of the arms, face, head, mouth, neck, or upper body
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
change in sex drive or performance
cough
drowsiness
dry mouth
headache
What may interact with this medicine?
Do not take this medicine with any of the following medications:
cisapride
dronedarone
fluconazole
pimozide
thioridazine
This medicine may also interact with the following medications:
alcohol
carbamazepine
certain medicines for anxiety, depression, or psychotic disturbances
certain medicines for blood pressure, heart disease, irregular heart beat
certain medications for Parkinson's disease like levodopa, bromocriptine, ropinirole, and pramipexole
certain medicines for sleep
narcotic pain medicines
other medicines that prolong the QT interval (cause an abnormal heart rhythm) like dofetilide
rifampin
St. John's Wort
What if I miss a dose?
Try to keep all appointments for your injections. This medicine is given either once every 4 weeks or once every 3 months depending on which type of injection your doctor has prescribed for you. Contact your health care provider for instructions if you miss an appointment.
Where should I keep my medicine?
This drug is given in a hospital or clinic and will not be stored at home.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
dementia
diabetes or family history of diabetes
heart disease
high blood pressure
history of irregular heartbeat
history of low white blood cell count
history of neuroleptic malignant syndrome
history of stroke
history of trouble controlling your muscles (tardive dyskinesia)
kidney disease
liver disease
low blood pressure
low levels of magnesium or potassium in the blood
seizures
stomach or intestine problems
an unusual or allergic reaction to paliperidone, risperidone, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
What should I watch for while using this medicine?
Your condition will be monitored carefully while you are receiving this medicine. It may be several weeks before you see the full effects. Do not stop this medicine except on the advice of your doctor or health care professional.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
This medicine may increase blood sugar. Ask your healthcare provider if changes in diet or medicines are needed if you have diabetes.
This drug can cause problems with controlling your body temperature. It can lower the response of your body to cold temperatures. If possible, stay indoors during cold weather. If you must go outdoors, wear warm clothes. It can also lower the response of your body to heat. Do not overheat. Do not over-exercise. Stay out of the sun when possible. If you must be in the sun, wear cool clothing. Drink plenty of water. If you have trouble controlling your body temperature, call your health care provider right away.
Updated:  
October 16, 2020