Omacetaxine mepesuccinate injection
Omacetaxine mepesuccinate injection
What is this medicine?
OMACETAXINE (OH ma se TAX een) is a chemotherapy drug. This medicine is used to treat chronic myelogenous leukemia.
How should I use this medicine?
This medicine is for injection under the skin. It is usually given by a health care professional in a hospital or clinic setting. If you get this medicine at home, you will be taught how to prepare and give this medicine. Refer to the Instructions for Use that come with your medication packaging. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed.
It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.
A special MedGuide will be given to you before each treatment. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
bloody or black, tarry stools
breathing problems
changes in vision
confusion, trouble speaking or understanding
fever or chills
increased hunger or thirst
increased urination
low blood counts
red or dark-brown urine
red spots on the skin
severe headaches
spitting up blood or brown material that looks like coffee grounds
unusual bruising or bleeding from the eye, gums, or nose
unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
constipation
diarrhea
hair loss
rash
stomach pain
vomiting
What may interact with this medicine?
This medicine may interact with the following:
aspirin
medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
NSAIDS, medicines for pain and inflammation, like ibuprofen or naproxen
What if I miss a dose?
It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment. If you give yourself the medicine and you miss a dose, skip the missed dose. Do not take double or extra doses.
Where should I keep my medicine?
Keep out of the reach of children.
If you are using this medicine at home, you will be instructed on how to store this medicine. Throw away any unused medicine after the expiration date on the label.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
bleeding disorder
diabetes
having surgery including dental surgery
an unusual or allergic reaction to omacetaxine, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
What should I watch for while using this medicine?
This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.
You may need blood work done while you are taking this medicine.
This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.
Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.
You may get drowsy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you.
Do not become pregnant while taking this medicine or for 6 months after stopping it. Women should inform their healthcare professional if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine or for 3 months after stopping it. There is a potential for serious effects to an unborn child. Talk to your healthcare professional for more information.
Do not breast-feed an infant while taking this medicine or for 2 weeks after stopping it.
This medicine may make it more difficult to father a child. You should talk with your doctor or health care professional if you are concerned about your fertility.
Updated:  
December 06, 2019