Metoclopramide oral disintegrating tablet

August 18, 2020

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Metoclopramide oral disintegrating tablet

What is this medicine?

METOCLOPRAMIDE (met oh kloe PRA mide) is used to treat the symptoms of gastroesophageal reflux disease (GERD) like heartburn. It is also used to relieve the symptoms of slow stomach emptying in people with diabetes.

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the prescription label. Take this medicine at least 30 minutes before eating and at bedtime. Leave the tablet in the sealed blister pack until you are ready to take it. With dry hands, open the blister and gently remove the tablet. If the tablet breaks or crumbles, throw it away and take a new tablet out of the blister pack. Place the tablet in the mouth and allow it to dissolve, and then swallow. You do not need water to take this medicine. Do not take your medicine more often than directed.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • abnormal production of milk

  • breast enlargement in both males and females

  • change in sex drive or performance

  • depressed mood

  • menstrual changes

  • restlessness, pacing, inability to keep still

  • signs and symptoms of neuroleptic malignant syndrome (NMS) like confusion; fast, irregular heartbeat; high fever; increased sweating; uncontrollable head, mouth, neck, arm, or leg movements; stiff muscles

  • seizures

  • suicidal thoughts, mood changes

  • swelling of the ankles, feet, hands

  • tremor

  • uncontrollable movements of the face, head, mouth, neck, arms, legs, or upper body

  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • dizziness

  • drowsiness

  • headache

  • tiredness

What may interact with this medicine?

  • alcohol

  • antihistamines for allergy, cough, and cold

  • atovaquone

  • atropine

  • bupropion

  • certain medicines for anxiety or sleep

  • certain medicines for bladder problems like oxybutynin, tolterodine

  • certain medicines for depression or psychotic disorders

  • certain medicines for Parkinson's disease

  • certain medicines for seizures like phenobarbital, primidone

  • certain medicines for stomach problems like dicyclomine, hyoscyamine

  • certain medicines for travel sickness like scopolamine

  • cyclosporine

  • digoxin

  • fosfomycin

  • general anesthetics like halothane, isoflurane, methoxyflurane, propofol

  • insulin and other medicines for diabetes

  • ipratropium

  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate

  • medicines that relax muscles for surgery

  • narcotic medicines for pain

  • paroxetine

  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine

  • posaconazole

  • quinidine

  • sirolimus

  • tacrolimus

What if I miss a dose?

If you miss a dose, skip it. Take your next dose at the normal time. Do not take extra or 2 doses at the same time to make up for the missed dose.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • breast cancer

  • depression

  • diabetes

  • heart failure

  • high blood pressure

  • if you often drink alcohol

  • kidney disease

  • liver disease

  • Parkinson's disease or a movement disorder

  • pheochromocytoma

  • seizures

  • stomach obstruction, bleeding, or perforation

  • an unusual or allergic reaction to metoclopramide, sulfites, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

It may take a few weeks for your condition to improve. Do not take this medicine for longer than 12 weeks. The longer you take this medicine and the more that you take, the more likely you are to have side effects. If you are an older patient, a female, or you have diabetes, you may be at increased risk for side effects. Contact your health care professional right away if you have movements that you cannot control such as lip smacking, rapid movements of the tongue, unusual movements of the eyes, head, or arms.

Patients and their families should watch out for worsening depression or thoughts of suicide. Also watch out for sudden changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.

Do not treat yourself for high fever. Ask your health care professional for advice.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Avoid alcoholic drinks.


August 18, 2020