Itraconazole oral solution

January 11, 2019

Itraconazole oral solution

What is this medicine?

ITRACONAZOLE (i tra KO na zole) is an antifungal medicine. It is used to treat certain kinds of fungal or yeast infections.

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the prescription label. Use a specially marked spoon, or container to measure your dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take this medicine on an empty stomach, at least 30 minutes before or 2 hours after food. Do not take with food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think you are better. Do not skip doses or stop your medicine early.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • changes in hearing

  • pain, tingling, numbness in the hands or feet

  • signs and symptoms of heart failure like breathing problems; fast, irregular heartbeat; sudden weight gain; swelling of the ankles, feet; unusually weak or tired

  • signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; right upper belly pain; yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • blurred vision

  • diarrhea

  • dizziness

  • headache

  • nausea, vomiting

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • alfuzosin

  • alprazolam

  • avanafil

  • certain medicines for blood pressure like felodipine, nisoldipine

  • certain medicines for cholesterol like cerivastatin, lovastatin, simvastatin, lomitapide

  • certain medicines for the heart like disopyramide, dofetilide, dronedarone, eplerenone, ivabradine, quinidine, ranolazine

  • cisapride

  • colchicine (if you have liver or kidney problems)

  • conivaptan

  • ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine

  • irinotecan

  • isavuconazole

  • lurasidone

  • methadone

  • midazolam

  • naloxegol

  • nevirapine

  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)

  • pimozide

  • red yeast rice

  • sirolimus

  • thioridazine

  • ticagrelor

  • triazolam

  • ziprasidone

This medicine may also interact with the following medications:

  • aliskiren

  • amlodipine

  • antacids

  • antiviral medicines for HIV or AIDS

  • aprepitant

  • atorvastatin

  • buprenorphine

  • certain antibiotics like ciprofloxacin, clarithromycin, erythromycin

  • certain medicines for bladder problems like fesoterodine, solifenacin, tolterodine

  • certain medicines for cancer like axitinib, bortezomib, busulfan, dabrafenib, dasatinib, docetaxel, erlotinib, gefitinib, ibrutinib, imatinib, ixabepilone, lapatinib, nilotinib, ponatinib, sunitinib, trabectedin, trimetrexate, vinca alkaloids

  • certain medicines for depression, anxiety, or psychotic disturbances like aripiprazole, buspirone, diazepam, haloperidol, perospirone, quetiapine, risperidone

  • certain medicines for erectile dysfunction like vardenafil, sildenafil, tadalafil

  • certain medicines for pain like alfentanil, fentanyl, oxycodone, sufentanil

  • certain medicines that treat or prevent blood clots like warfarin, dabigatran, rivaroxaban

  • certain medicines for seizures like carbamazepine, phenytoin

  • certain medicines for tuberculosis like isoniazid, INH, rifabutin, rifampin, rifapentine

  • cilostazol

  • cinacalcet

  • cyclosporine

  • digoxin

  • eletriptan

  • everolimus

  • halofantrine

  • isradipine

  • meloxicam

  • nadolol

  • nifedipine

  • other medicines for fungal infections

  • praziquantel

  • ramelteon

  • repaglinide

  • salmeterol

  • saxagliptin

  • steroid medicines like budesonide, ciclesonide, dexamethasone, fluticasone, methylprednisolone

  • tacrolimus

  • tamsulosin

  • tolvaptan

  • verapamil

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature, 25 degrees C (77 degrees F). Protect from light and moisture. Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • heart disease

  • history of irregular heartbeat

  • immune system problems

  • kidney disease

  • liver disease

  • lung or breathing disease

  • an unusual or allergic reaction to itraconazole, or other antifungal medicines, foods, dyes or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how the medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.


January 11, 2019