Isoproterenol
Isoproterenol inhalation aerosol
What is isoproterenol inhalation aerosol?
ISOPROTERENOL (Isuprel®, Medihaler-Iso™) opens up air passages to make breathing easier for people with various lung problems such as severe asthma. The brand names listed are not interchangeable products. Do not change the brand of inhaler you use without your prescriber or health care professional's advice. Generic isoproterenol inhalation aerosol is available.
What should my health care professional know before I use isoproterenol?
They need to know if you have any of the following conditions:
asthma or other diseases which affect your breathing
diabetes
heart or kidney disease
high blood pressure
over active thyroid
pheochromocytoma
an unusual or allergic reaction to isoproterenol, sulfites, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How should I use this medicine?
Isoproterenol aerosol is for inhalation through the mouth. Shake the canister well. Tilt your head back slightly. Breathe out fully, emptying as much air as possible from your lungs. Keep the canister upright. Keep the inhaler about 1 inch from your open mouth (or place the mouthpiece loosely between your open lips). Press down on the inhaler (one puff) while breathing in deeply and slowly. Hold your breath for at least 10 seconds and then exhale (breathe out). Wait for at least 1 to 2 minutes between puffs. Do not use more than two puffs at a time, unless your prescriber or health care professional tells you otherwise.
What if I miss a dose?
If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.
What drug(s) may interact with isoproterenol?
amphotericin B
beta blockers, often used for high blood pressure or heart problems
bromocriptine
heart medicine
hormones such as prednisone or cortisone
insulin
levodopa
linezolid
medicines for chest pain
medicines for colds and breathing difficulties including asthma
medicines for high blood pressure
medicines for mental depression
medicines for migraine
penicillin antibiotics
maprotiline
some medications for Parkinson's disease, such as entacapone, levodopa or tolcapone
theophylline
water pills
Tell your prescriber or health care professional about all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check before starting or stopping any of your medicines.
What should I watch for while taking isoproterenol?
Check with your prescriber or health care professional if your symptoms do not improve with isoproterenol inhalation, or if they get worse. You may need a change of therapy. Make sure you are using your inhaler properly. Do not use extra or more frequent inhalations; they will not improve your condition.
Isoproterenol may give your saliva or sputum a pink color. This is no cause for concern.
To keep your mouth from getting dry after inhaling isoproterenol, rinse out your mouth with water.
Do not get the aerosol spray in your eyes.
If you also use ipratropium (Atrovent®) or an inhaled steroid (such as beclomethasone or triamcinolone), use the isoproterenol first. Wait at least 5 minutes before using the other inhaler.
If you are going to have surgery, tell your prescriber or health care professional that you are using isoproterenol.
Do not treat yourself for coughs, colds or allergies without checking with your prescriber or health care professional. Nonprescription medicines may contain ingredients that will increase the effects of your medicine.
What side effects may I notice from using isoproterenol?
Side effects that you should report to your prescriber or health care professional as soon as possible:
difficulty breathing, wheezing
flushing (reddening of the skin)
palpitations, chest pain
numbness in fingers or toes
skin rash, hives
swelling of the lips or face
vomiting
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
anxiety or nervousness
cough
dry mouth
drowsiness or dizziness
headache
increased sweating
nausea
pink coloration of saliva
weakness or tiredness
Where can I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F); do not freeze. Protect from light. Throw away any unused medicine after the expiration date.
Isoproterenol inhalation solution
What is isoproterenol inhalation solution?
ISOPROTERENOL (Isuprel®) opens up air passages to make breathing easier for people with various lung problems such as severe asthma. Generic isoproterenol inhalation solution is available.
What should my health care professional know before I use isoproterenol?
They need to know if you have any of the following conditions:
asthma or other diseases which affect your breathing
diabetes
heart or kidney disease
high blood pressure
over active thyroid
pheochromocytoma
an unusual or allergic reaction to isoproterenol, sulfites, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How should I use this medicine?
Isoproterenol inhalation solution is for use with a nebulizer. Nebulizers convert a solution of isoproterenol into an aerosol for inhalation through the mouth. The flow rate is adjusted to provide a correct dose. Make sure you know how to use the nebulizer correctly. Ask your prescriber or health care professional if you have problems. Do not use more often than directed.
What if I miss a dose?
If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.
What drug(s) may interact with isoproterenol?
amphotericin B
beta blockers, often used for high blood pressure or heart problems
bromocriptine
heart medicine
hormones such as prednisone or cortisone
insulin
linezolid
medicines for chest pain
medicines for colds and breathing difficulties including asthma
medicines for high blood pressure
medicines for mental depression
medicines for migraine
penicillin antibiotics
maprotiline
some medications for Parkinson's disease, such as entacapone, levodopa or tolcapone
theophylline
water pills
Tell your prescriber or health care professional about all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check before starting or stopping any of your medicines.
What should I watch for while taking isoproterenol?
Check with your prescriber or health care professional if your symptoms do not improve with isoproterenol inhalation, or if they get worse. You may need a change of therapy. Make sure you are using your nebulizer properly. Do not use extra or more frequent inhalations; they will not improve your condition.
Isoproterenol may give your saliva or sputum a pink color. This is no cause for concern.
To keep your mouth from getting dry after inhaling isoproterenol, rinse out your mouth with water.
If you also use ipratropium (Atrovent®) or an inhaled steroid (such as beclomethasone or triamcinolone), use the isoproterenol first. Wait at least 5 minutes before using the other inhaler.
If you are going to have surgery, tell your prescriber or health care professional that you are using isoproterenol.
Do not use an isoproterenol solution that appears cloudy, pinkish, or brownish.
Do not treat yourself for coughs, colds or allergies without checking with your prescriber or health care professional. Nonprescription medicines may contain ingredients that will increase the effects of your medicine.
What side effects may I notice from using isoproterenol?
Side effects that you should report to your prescriber or health care professional as soon as possible:
difficulty breathing, wheezing
flushing (reddening of the skin)
palpitations, chest pain
numbness in fingers or toes
skin rash, hives
swelling of the lips or face
vomiting
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
anxiety or nervousness
cough
dry mouth
drowsiness or dizziness
headache
increased sweating
nausea
pink coloration of saliva
weakness or tiredness
Where can I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F); do not freeze. Protect from light. Throw away any unused medicine after the expiration date.
Isoproterenol injection
What is isoproterenol injection?
ISOPROTERENOL (Isuprel®) can help to treat certain heart problems. It can be used in an emergency to strengthen heart beat and to treat an irregular heart beat. Isoproterenol can also relieve bronchospasm that may occur during anesthesia. Generic isoproterenol injections are available.
What should my health care professional know before I receive isoproterenol?
They need to know if you have any of the following conditions:
asthma or other diseases which affect your breathing
diabetes
heart or kidney disease
high blood pressure
over active thyroid
pheochromocytoma
an unusual or allergic reaction to isoproterenol, sulfites, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How should I use this medicine?
Isoproterenol is for injection or infusion into a vein. In some cases injection can be given into a muscle or under the skin. It is given by a health care professional in a hospital or clinic setting.
What if I miss a dose?
This does not apply.
What drug(s) may interact with isoproterenol?
amphotericin B
beta blockers, often used for high blood pressure or heart problems
bromocriptine
heart medicine
hormones such as prednisone or cortisone
insulin
linezolid
medicines for chest pain
medicines for colds and breathing difficulties including asthma
medicines for high blood pressure
medicines for mental depression
medicines for migraine
penicillin antibiotics
maprotiline
some medications for Parkinson's disease, such as entacapone, levodopa or tolcapone
theophylline
water pills
Tell your prescriber or health care professional about all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check before starting or stopping any of your medicines.
What should I watch for while taking isoproterenol?
This does not apply as your condition will be closely monitored during use of isoproterenol.
Do not treat yourself for coughs, colds or allergies without checking with your prescriber or health care professional. Nonprescription medicines may contain ingredients that will increase the effects of your medicine.
What side effects may I notice from receiving isoproterenol?
Side effects that you should report to your prescriber or health care professional as soon as possible:
difficulty breathing, wheezing
dizziness or fainting spells
flushing (reddening of the skin)
irregular heartbeats, palpitations, chest pain
numbness in fingers or toes
skin rash, hives
swelling of the lips or face
vomiting
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
anxiety or nervousness
headache
increased sweating
nausea
weakness or tiredness
Where can I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 8 and 15 degrees C (46 and 59 degrees F); do not freeze. Protect from light. Do not use if discolored or if particulate matter is present. Throw away any unused medicine after the expiration date.
Isoproterenol sublingual tablets
What are isoproterenol sublingual tablets?
ISOPROTERENOL (Isuprel®) opens up air passages to make breathing easier for people with various lung problems such as severe asthma. Generic isoproterenol sublingual tablets are not available.
What should my health care professional know before I take isoproterenol?
They need to know if you have any of the following conditions:
asthma or other diseases which affect your breathing
diabetes
heart or kidney disease
high blood pressure
over active thyroid
pheochromocytoma
an unusual or allergic reaction to isoproterenol, sulfites, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How should I take this medicine?
Place an isoproterenol sublingual tablet under the tongue and let it dissolve slowly in the mouth; do not chew or swallow whole. Make sure your mouth is not dry; saliva around the tablet will help it to dissolve more quickly. Do not eat, drink, smoke, or chew tobacco while a tablet is dissolving. Do not take isoproterenol sublingual tablets more frequently than every 3 to 4 hours, or more often than 3 times a day.
What if I miss a dose?
If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.
What drug(s) may interact with isoproterenol?
amphotericin B
beta blockers, often used for high blood pressure or heart problems
bromocriptine
heart medicine
hormones such as prednisone or cortisone
insulin
levodopa
linezolid
medicines for chest pain
medicines for colds and breathing difficulties including asthma
medicines for high blood pressure
medicines for mental depression
medicines for migraine
penicillin antibiotics
maprotiline
some medications for Parkinson's disease, such as entacapone, levodopa or tolcapone
theophylline
water pills
Tell your prescriber or health care professional about all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check before starting or stopping any of your medicines.
What should I watch for while taking isoproterenol?
Check with your prescriber or health care professional if your symptoms do not improve with isoproterenol, or if they get worse. You may need a change of therapy.
Isoproterenol may give your saliva or sputum a pink color. This is no cause for concern.
If you use isoproterenol tablets too often, the acidity can damage your teeth. Check regularly with your dentist .
If you are going to have surgery, tell your prescriber or health care professional that you are using isoproterenol.
Do not treat yourself for coughs, colds or allergies without checking with your prescriber or health care professional. Nonprescription medicines may contain ingredients that will increase the effects of your medicine.
What side effects may I notice from taking isoproterenol?
Side effects that you should report to your prescriber or health care professional as soon as possible:
difficulty breathing, wheezing
flushing (reddening of the skin)
palpitations, chest pain
numbness in fingers or toes
skin rash, hives
swelling of the lips or face
vomiting
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
anxiety or nervousness
cough
dry mouth
drowsiness or dizziness
headache
increased sweating
nausea
pink coloration of saliva
weakness or tiredness
Where can I keep my medicine?
Keep out of the reach of children in a container that small children cannot open.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date.
Updated:  
March 21, 2017
Sources:  
U.S. FDA-approved Package Insert