Ibrutinib capsules and tablets
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Ibrutinib capsules and tablets
What is this medicine?
IBRUTINIB (eye BROO ti nib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat mantle cell lymphoma, chronic lymphocytic leukemia, small lymphocytic lymphoma, marginal zone lymphoma, Waldenstrom macroglobulinemia, and chronic graft-versus-host disease.
How should I use this medicine?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. Do not take with grapefruit juice or eat Seville oranges. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
low blood counts - this medicine may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk for infections and bleeding
signs or symptoms of bleeding such as bloody or black, tarry stools; red or dark-brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eye, gums, or nose; confusion; trouble speaking or understanding; severe headaches; weakness; or dizziness
signs and symptoms of a dangerous change in heartbeat or heart rhythm like chest pain; dizziness; fast or irregular heartbeat; palpitations; feeling faint or lightheaded, falls; breathing problems
signs and symptoms of infection like fever or chills; cough; sore throat; or pain when urinating
signs and symptoms of kidney injury like trouble passing urine or change in the amount of urine
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
bone pain
diarrhea
mouth sores
muscle cramps
muscle pain
nausea
tiredness
What may interact with this medicine?
Do not take this medicine with any of the following medications:
atazanavir
atazanavir; cobicistat
darunavir
darunavir; cobicistat
darunavir; cobicistat; emtricitabine; tenofovir alafenamide
delavirdine
fosamprenavir
tipranavir
This medicine may interact with the following medications:
antiviral medications for HIV or AIDS
aprepitant
calcium channel blockers like diltiazem and verapamil
certain antibiotics like clarithromycin, erythromycin, and troleandomycin
certain medicines for fungal infections like fluconazole, ketoconazole, itraconazole, posaconazole, and voriconazole
certain medicines for seizures like carbamazepine and phenytoin
cimetidine
ciprofloxacin
clotrimazole
conivaptan
crizotinib
cyclosporine
digoxin
dronedarone
enzalutamide
fluvoxamine
grapefruit juice or Seville oranges
idelalisib
imatinib
methotrexate
mitotane
nefazodone
rifampin
St. John's wort
tofisopam
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Where should I keep my medicine?
Keep out of the reach of children.
Store between 20 and 25 degrees C (68 and 77 degrees F). Keep this medicine in the original container. Throw away any unused medicine after the expiration date.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
bleeding disorders
diabetes
heart disease
high blood pressure
high cholesterol
history of irregular heartbeat
infection
liver disease
recent surgery
smoke tobacco
take medicines that treat or prevent blood clots
an unusual or allergic reaction to ibrutinib, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
What should I watch for while using this medicine?
You may need blood work done while you are taking this medicine.
This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.
If you are going to have surgery or any other procedures, tell your doctor you are taking this medicine. Tell your dentist and dental surgeon that you are taking this medicine. You should not have major dental surgery while on this medicine. See your dentist to have a dental exam and fix any dental problems before starting this medicine.
Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine.
Do not become pregnant while taking this medicine or for 1 month after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 1 month after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.
Do not breast-feed an infant while taking this medicine or for 1 week after stopping it.
Updated:  
November 22, 2020