Hylan G-F 20 intra-articular injection

What is this medicine?

HYLAN G-F 20 (HI lan G F 20) is used to treat osteoarthritis of the knee. It lubricates and cushions the joint, reducing pain in the knee.

How should I use this medicine?

This medicine is for injection into the knee joint. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

• difficulty breathing

• fever or chills

• severe joint pain or swelling

• unusual bleeding or bruising

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• dizziness

• flushing

• general ill feeling or flu-like symptoms

• headache

• minor joint pain or swelling

• muscle pain or cramps

• pain, redness, irritation or bruising at site of injection

What may interact with this medicine?

Do not take this medicine with any of the following medications:

• other injections for the joint like steroids or anesthetics

• certain skin disinfectants like benzalkonium chloride

What if I miss a dose?

Keep appointments for follow-up doses as directed. For Synvisc, you will need weekly injections for 3 doses. It is important not to miss your dose. If you will receive Synvisc-One, then only 1 injection will be needed. Call your doctor or health care professional if you are unable to keep an appointment.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• severe knee inflammation

• skin conditions or sensitivity

• skin or joint infection

• venous stasis

• an unusual or allergic reaction to hylan G-F 20, hyaluronan (sodium hyaluronate), eggs, other medicines, foods, dyes, or preservatives

• pregnant or trying to get pregnant

• breast-feeding

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Your condition will be monitored carefully while you are receiving this medicine. Most persons get pain relief for up to 6 months after treatment.

Avoid strenuous activities (high-impact sports, jogging) or major weight-bearing activities for 48 hours after the injection.