Hyaluronidase
Hyaluronidase Solution for injection
What is this medicine?
HYALURONIDASE (hye al ur ON i dase) is a natural protein. It is used to improve the effects of other injectable medicines given with this medicine.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
allergy to bee stings or other insects
infection in the area where injection is planned
an unusual or allergic reaction to hyaluronidase, beef proteins, thimerosal, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How should I use this medicine?
This medicine is for injection under the skin or into a muscle. It is given by a health care professional in a hospital or clinic setting.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as newborn for selected conditions, precautions do apply.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
This does not apply.
What may interact with this medicine?
ACTH
antihistamines for allergy or cold
aspirin and aspirin-like medicines
benzodiazepines for anxiety or sleep
female hormones like estrogens
furosemide
phenytoin
steroid medicines like prednisone or cortisone
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Your condition will be monitored carefully while you are receiving this medicine. Visit your doctor for check-ups as directed.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
breathing problems
chest pain
chills
fast, irregular heartbeat
feeling faint or lightheaded, falls
nausea or vomiting
swelling at site where injected
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
inflammation, redness or pain at site where injected
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
This drug is given in a hospital or clinic and will not be stored at home.
Hyaluronidase Solution for injection
What is this medicine?
HYALURONIDASE (hye al ur ON i dase) is a natural protein. It is used to improve the effects of other injectable medicines given with this medicine.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
allergy to bee stings or other insects
infection in the area where injection is planned
an unusual or allergic reaction to hyaluronidase, sheep proteins, beef proteins, thimerosal, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How should I use this medicine?
This medicine is for injection under the skin or into a muscle. It is given by a health care professional in a hospital or clinic setting.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as newborn for selected conditions, precautions do apply.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
This does not apply.
What may interact with this medicine?
ACTH
antihistamines for allergy or cold
aspirin and aspirin-like medicines
benzodiazepines for anxiety or sleep
female hormones like estrogens
furosemide
phenytoin
steroid medicines like prednisone or cortisone
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Your condition will be monitored carefully while you are receiving this medicine. Visit your doctor for check-ups as directed.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
breathing problems
chest pain
chills
fast, irregular heartbeat
feeling faint or lightheaded, falls
nausea or vomiting
swelling at site where injected
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
inflammation, redness or pain at site where injected
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
This drug is given in a hospital or clinic and will not be stored at home.
Updated:  
March 21, 2017
Sources:  
U.S. FDA-approved Package Insert