Fluconazole injection

What is this medicine?

FLUCONAZOLE (floo KON na zole) is an antifungal medicine. It is used to treat or prevent certain kinds of fungal or yeast infections.

How should I use this medicine?

This medicine is for injection into a vein. It is usually given by a health care professional in a hospital or clinic setting.

If you get this medicine at home, you will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash or itching, hives, swelling of the lips, mouth, tongue, or throat

• dark urine

• feeling dizzy or faint

• irregular heartbeat or chest pain

• pain, redness at site of injection

• redness, blistering, peeling or loosening of the skin, including inside the mouth

• stomach pain

• trouble breathing

• unusual bruising or bleeding

• vomiting

• yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• changes in how food tastes

• diarrhea

• headache

• stomach upset, nausea

What may interact with this medicine?

Do not take this medicine with any of the following medications:

• astemizole

• certain medicines for irregular heart beat like dronedarone, quinidine

• cisapride

• erythromycin

• lomitapide

• other medicines that prolong the QT interval (cause an abnormal heart rhythm) like encorafenib, lapatinib

• pimozide

• terfenadine

• thioridazine

This medicine may also interact with the following medications:

• antiviral medicines for HIV or AIDS

• birth control pills

• certain antibiotics like rifabutin, rifampin

• certain medicines for blood pressure like amlodipine, isradipine, felodipine, hydrochlorothiazide, losartan, nifedipine

• certain medicines for cancer like cyclophosphamide, ibrutinib, vinblastine, vincristine

• certain medicines for cholesterol like atorvastatin, lovastatin, fluvastatin, simvastatin

• certain medicines for depression, anxiety, or psychotic disturbances like amitriptyline, midazolam, nortriptyline, triazolam

• certain medicines for diabetes like glipizide, glyburide, tolbutamide

• certain medicines for pain like alfentanil, fentanyl, methadone

• certain medicines for seizures like carbamazepine, phenytoin

• certain medicines that treat or prevent blood clots like warfarin

• dofetilide

• halofantrine

• medicines that lower your chance of fighting infection like cyclosporine, prednisone, tacrolimus

• NSAIDS, medicines for pain and inflammation, like celecoxib, diclofenac, flurbiprofen, ibuprofen, meloxicam, naproxen

• other medicines for fungal infections

• sirolimus

• theophylline

• tofacitinib

• tolvaptan

• ziprasidone

What if I miss a dose?

This does not apply.

Where should I keep my medicine?

Keep out of the reach of children.

If you are using this medicine at home, you will be instructed on how to store this medicine. Throw away any unused medicine after the expiration date on the label.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• history of irregular heart beat

• kidney disease

• an unusual or allergic reaction to fluconazole, other antifungal medicines, foods, dyes or preservatives

• pregnant or trying to get pregnant

• breast-feeding

What should I watch for while using this medicine?

Tell your doctor if your symptoms do not improve. If you are taking this medicine for a long time you may need blood work. Some fungal infections need many weeks or months of treatment to cure completely.

Alcohol can increase possible damage to your liver from this medicine. Avoid alcoholic drinks.