Elosulfase alfa solution for injection

What is this medicine?

ELOSULFASE ALFA (el oh SUL fase AL fa) is an enzyme replacement. It is used to treat the symptoms of Mucopolysaccharidosis type IVA (MPS IVA; Morquio A syndrome). This medicine is not a cure.

How should I use this medicine?

This medicine is for infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of the medicine in children. While this drug may be prescribed for children as young as 5 years of age for selected conditions, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

• breathing problems

• chest pain or chest tightness

• cough

• low blood pressure

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• chills

• fever

• headache

• nausea, vomiting

• stomach pain

• tiredness

What may interact with this medicine?

Interactions have not been studied.

What if I miss a dose?

It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• fever or infection

• sleep apnea

• an unusual or allergic reaction to elosulfase alfa, other medicines, foods, dyes, or preservatives

• pregnant or trying to get pregnant

• breast-feeding

What should I watch for while using this medicine?

This medicine can cause serious allergic reactions. To reduce your risk you may need to take medicine before treatment with this medicine. Take your medicine as directed.

Your condition will be monitored carefully while you are receiving this medicine.