What is this medicine?
DENOSUMAB (den oh sue mab) slows bone breakdown. Prolia is used to treat osteoporosis in women after menopause and in men. Xgeva is used to prevent bone fractures and other bone problems caused by cancer bone metastases. Xgeva is also used to treat giant cell tumor of the bone.
How should I use this medicine?
This medicine is for injection under the skin. It is given by a health care professional in a hospital or clinic setting.
If you are getting Prolia, a special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
For Prolia, talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. For Xgeva, talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 13 years for selected conditions, precautions do apply.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
fast, irregular heartbeat
feeling faint or lightheaded, falls
fever, chills, or any other sign of infection
muscle spasms, tightening, or twitches
numbness or tingling
skin blisters or bumps, or is dry, peels, or red
slow healing or unexplained pain in the mouth or jaw
unusual bleeding or bruising
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
stomach upset, gas
What may interact with this medicine?
Do not take this medicine with any of the following medications:
other medicines containing denosumab
This medicine may also interact with the following medications:
medicines that suppress the immune system
medicines that treat cancer
steroid medicines like prednisone or cortisone
What if I miss a dose?
It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.
Where should I keep my medicine?
This medicine is only given in a clinic, doctor's office, or other health care setting and will not be stored at home.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
infection or history of infections
kidney disease or on dialysis
low blood calcium or vitamin D
scheduled to have surgery or tooth extraction
taking medicine that contains denosumab
thyroid or parathyroid disease
an unusual reaction to denosumab, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
What should I watch for while using this medicine?
Visit your doctor or health care professional for regular checks on your progress. Your doctor or health care professional may order blood tests and other tests to see how you are doing.
Call your doctor or health care professional if you get a cold or other infection while receiving this medicine. Do not treat yourself. This medicine may decrease your body's ability to fight infection.
You should make sure you get enough calcium and vitamin D while you are taking this medicine, unless your doctor tells you not to. Discuss the foods you eat and the vitamins you take with your health care professional.
See your dentist regularly. Brush and floss your teeth as directed. Before you have any dental work done, tell your dentist you are receiving this medicine.
Do not become pregnant while taking this medicine or for 5 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.
September 30, 2017