Aflibercept Solution for injection

What is this medicine?

AFLIBERCEPT (a FLIB er sept) is an injectable medicine for the eye. It is used to treat wet age-related macular degeneration (AMD) and macular edema, including diabetic macular edema. This drug is also used to treat diabetic retinopathy in patients with diabetic macular edema. This medicine helps to slow the disease and may help to maintain vision. It is not a cure.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• eye infection

• eye inflammation

• glaucoma

• recent eye surgery

• an unusual or allergic reaction to aflibercept, other medicines, foods, dyes, or preservatives

• pregnant or trying to get pregnant

• breast-feeding

How should I use this medicine?

This medicine is injected into the eye by an eye doctor who specializes in this treatment.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medicine?

Interactions are not expected. Do not use any other eye products without talking to your doctor or health care professional.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.

If you are a woman, use effective birth control before your first dose, during your treatment, and for at least 3 months after your last dose.

Tell your doctor or health care professional right away if you have any change in your eyesight. This medicine may cause temporary blurred vision. Do not drive or use machinery until your vision has returned to normal.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

• bleeding in eye

• changes in vision

• confusion, trouble speaking or understanding

• eye pain

• sensitivity to light

• severe headaches

• sudden numbness or weakness of the face, arm or leg

• swelling or redness of the eye or eyelid

• trouble walking, dizziness, loss of balance or coordination

Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.):

• feeling of something in the eye

• increased tearing

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.