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Bullous pemphigoid is an autoimmune disease. That’s when the immune system attacks healthy parts of the body. In this case, it attacks the proteins that join the skin cells to one another. The disease may also be caused by some medicines, such as penicillin.

Bullous pemphigoid may first look like hives or eczema, because it can be red and itchy. Large, firm blisters may then form. These blisters are often filled with a clear liquid. They may feel very itchy. The blisters may pop. But they usually don’t leave any scars. They may go away and come back again.

The blisters from this skin disease may go away and come back. So treatment is often needed for a few years. Treatment options include:

• Skin care. Using mild soap and anti-itch creams may help with symptoms.

• Steroids. Steroids are the main treatment option for this disease. They may be creams or ointments that you put on your skin. Or they may be in pill or liquid form (oral). They can ease itching and stop new blisters from forming. But oral steroids may have side effects.

• Other medicines. To avoid long term complications of oral steroids, other medications may be added or used instead. Some of these treat the disease by slowing down the immune system.

•  Skin infection

Call your healthcare provider right away if you have any of these:

• Fever of 100.4°F (38°C) or higher, or as directed

• Pain that gets worse

• Symptoms that don’t get better, or get worse

• New symptoms