To understand genomics, we have to first grasp genetics. Still reading? It’s not as complicated as most of us believe.
Genetics, or the study of heredity, is what makes you different from everyone else. Your eyes may be brown and your best friend’s are blue. You’re unique because of your genes. However, all of us are 99.9 percent identical in our genetic makeup. Only 0.1 percent of our genetic makeup differs, and that holds important clues about the causes of diseases.
Genetics studies the function and composition of a single gene; genomics looks at all of your genes and how they interact and function. That complete set, or DNA sequence, is called a genome. Genomics also includes the scientific study of a wide array of diseases.
It gives doctors many possibilities for therapies and treatments of complex illnesses. James Watson, PhD, an American molecular biologist, geneticist, and zoologist, best known as one of the discoverers of the structure of DNA, stated that the completed map of the human genome would serve as the official instruction book for human life. According to Watson and other geneticists, genomics provides scientists with vital information about genetic diseases and traits.
Watson and others believe that thanks to genomics, doctors will be able to cure diseases like Alzheimer’s, diabetes, and cancer by attacking the genetic roots of these diseases. Understanding how genes affect diseases leads to new treatments.
Genomics also looks at environmental factors and behaviors. Scientists are using genomics to unlock the reasons why someone who smokes their entire life and doesn’t exercise lives to age 90, while someone who eats a healthy diet and spends their spare time at the gym develops heart disease.
Barry Schuler, managing director for DFJ Growth and the former chair and CEO of America Online, asked at a TED Talk, “Why does a cell go from a normal cell to one with cancer? What is the code? What are the exact instructions that are making it do that? Once we know then you can go about the process and try to fix it and figure it out.”
Schuler said that once we’re able to understand how illness works at the genomic level, then we will be able to cure disease.
The benefits are huge. The experts say genomics will:
Looking ahead, the National Institutes of Health recently issued four new studies on the ethical, legal, and social impact of genomics. Their grants, which total close to $15 million over a four-year period:
The medical community is also hosting several conferences on genomic medicine. One such conference in California in 2017 aims to use genomic knowledge to change medicine so it will be more precise and individualized.
July 27, 2016
Christopher Nystuen, MD, MBA