Liverwort (Hepatica ssp.)
Natural Standard Bottom Line Monograph, Copyright © 2013 (www.naturalstandard.com). Commercial distribution prohibited. This monograph is intended for informational purposes only, and should not be interpreted as specific medical advice. You should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.
While some complementary and alternative techniques have been studied scientifically, high-quality data regarding safety, effectiveness, and mechanism of action are limited or controversial for most therapies. Whenever possible, it is recommended that practitioners be licensed by a recognized professional organization that adheres to clearly published standards. In addition, before starting a new technique or engaging a practitioner, it is recommended that patients speak with their primary healthcare provider(s). Potential benefits, risks (including financial costs), and alternatives should be carefully considered. The below monograph is designed to provide historical background and an overview of clinically-oriented research, and neither advocates for or against the use of a particular therapy.
Hepatica, Hepatica nobilis, Hepatica transsilvanica, liverleaf, Ranunculaceae (family), sesquiterpene lactone.
Note: Liverwort (Hepatica ssp.) should not be confused with Jungermannia ssp., Bazzania ssp., Lepidolaena ssp., Marchantia ssp., Riccardia ssp., Plagiochila ssp., or Frullania ssp., although they are also commonly called liverworts.
Liverwort (Hepatica ssp.) is the common name for a genus of herbaceous perennial plants native to central and northern Europe, Asia, and northeastern North America. Liverwort (Hepatica ssp.) should not be confused with Jungermannia ssp., Bazzania ssp., Lepidolaena ssp., Marchantia ssp., Riccardia ssp., Plagiochila ssp., or Frullania ssp., although they are also commonly called liverworts. There is little scientific evidence currently available on the uses of liverwort. One laboratory study indicates that derivatives of liverwort may affect lipid (fat) homeostasis. Liverwort is not listed on the U.S. Food and Drug Administration's Generally Recognized as Safe (GRAS) list.
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
No available studies qualify for inclusion in the evidence table.
*Key to grades:A: Strong scientific evidence for this use; B: Good scientific evidence for this use; C: Unclear scientific evidence for this use; D: Fair scientific evidence against this use (it may not work); F: Strong scientific evidence against this use (it likely does not work).
The below uses are based on tradition or scientific theories. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious and should be evaluated by a qualified health care professional.
Insufficient available evidence.
The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.
Avoid in individuals with a known allergy or hypersensitivity to liverwort. Liverwort may cause contact hypersensitivity, such as skin rash.
Side Effects and Warnings
There is very little available information reported on adverse effects. Liverwort is not listed on the U.S. Food and Drug Administration's Generally Recognized as Safe (GRAS) list. Use cautiously in patients sensitive to liverwort. In a case report, liverwort was associated with contact hypersensitivity.
Use cautiously in patients with hypercholesterolemia (high cholesterol) as liverwort may alter lipid levels.
Pregnancy and Breastfeeding
Liverwort is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.
Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.
Interactions with Drugs
Liverwort may alter serum lipid levels (fat levels in the blood). Use cautiously with cholesterol-lowering medications, due to possible additive effects.
Interactions with Herbs and Dietary Supplements
Liverwort may alter serum lipid levels (fat levels in the blood). Use cautiously with cholesterol-lowering herbs and supplements, due to possible additive effects.
This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).
Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Knoche H, Ourisson G, Perold GW, et al. Allergenic component of a liverwort: a sesquiterpene lactone. Science 10-10-1969;166(902):239-240. View Abstract
Storrs FJ, Mitchell JC, Rasmussen JE. Contact hypersensitivity to liverwort and the compositae family of plants. Cutis 1976;18(5):681-686. View Abstract
Tamehiro N, Sato Y, Suzuki T, et al. Riccardin C: a natural product that functions as a liver X receptor (LXR)alpha agonist and an LXRbeta antagonist. FEBS Lett 10-10-2005;579(24):5299-5304. View Abstract
Copyright © 2013 Natural Standard (www.naturalstandard.com)
The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
March 22, 2017