Natural Standard Bottom Line Monograph, Copyright © 2013 (www.naturalstandard.com). Commercial distribution prohibited. This monograph is intended for informational purposes only, and should not be interpreted as specific medical advice. You should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.
While some complementary and alternative techniques have been studied scientifically, high-quality data regarding safety, effectiveness, and mechanism of action are limited or controversial for most therapies. Whenever possible, it is recommended that practitioners be licensed by a recognized professional organization that adheres to clearly published standards. In addition, before starting a new technique or engaging a practitioner, it is recommended that patients speak with their primary healthcare provider(s). Potential benefits, risks (including financial costs), and alternatives should be carefully considered. The below monograph is designed to provide historical background and an overview of clinically-oriented research, and neither advocates for or against the use of a particular therapy.
Anthozoa (class), Bio-Eye® hydroxyapatite implant, calcium carbonate matrix, carbonate bone replacement graft (BRG), coral carbonate, coral grafts, Coral Water™, coralline, Goniopora species, hydroxyapatite, natural coral, natural coral calcium, NC (porites), sea coral calcite.
Note: This review does not include a detailed description of calcium.
Corals are sea animals that grow in colonies. Corals are most often found in tropical oceans and are known as reef builders because they secrete calcium carbonate to form a hard skeleton.
Natural and man-made coral are currently being studied for use in bone grafts. Coral has been shown to increase bone strength when incorporated into surrounding bone.
Although coral may be useful as a bone graft substitute, researchers state that more long-term information on safety and effectiveness is needed. Coral has been associated with an increased rate of infection and may cause problems in those who have or are prone to kidney stones.
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Bone healing (reconstructive surgery and grafting)
Coral may strengthen bone. Natural and man-made coral are currently being studied for use as substitutes for bone grafts.
*Key to grades:A: Strong scientific evidence for this use; B: Good scientific evidence for this use; C: Unclear scientific evidence for this use; D: Fair scientific evidence against this use (it may not work); F: Strong scientific evidence against this use (it likely does not work).
The below uses are based on tradition or scientific theories. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious and should be evaluated by a qualified health care professional.
Arthritis, cancer, heart disease.
The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.
Adults (18 years and older)
There is no proven safe or effective dose for coral.
Children (under 18 years old)
There is no proven safe or effective dose for coral. Use in children is not recommended.
The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.
Avoid with allergy or hypersensitivity to coral.
Side Effects and Warnings
Coral should be avoided in people who have or are prone to kidney disease or kidney stones. Coral may increase the risk of infection and wound irritation when used for bone grafting.
Pregnancy and Breastfeeding
Coral is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.
Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.
Interactions with Drugs
Coral, which contains calcium, may theoretically interact with blood pressure medications called calcium channel blockers (such as verapamil or diltiazem).
Interactions with Herbs and Dietary Supplements
Coral contains calcium and may have additive effects when take with other supplements containing calcium, especially in people who have kidney problems or kidney stones.
This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).
Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Bizette C, Raul JS, Orhan B, et al. [Results of cervical interbody fusion with coral grafts]. Neurochirurgie 1999;45(1):4-14. View Abstract
Boutault F, Cantaloube D, Testelin S, et al. [Role of coral blocks in cheek augmentation surgery. Prospective study of 23 patients]. Ann Chir Plast Esthet. 1997;42(3):216-222. View Abstract
Jordan DR, Gilberg S, Mawn L, et al. The synthetic hydroxyapatite implant: a report on 65 patients. Ophthal Plast Reconstr Surg. 1998;14(4):250-255. View Abstract
Marchac D, Sandor G. Use of coral granules in the craniofacial skeleton. J Craniofac Surg. 1994;5(4):213-217. View Abstract
Martov AG. [The place of supravesical endourology in the modern combined treatment of urolithiasis]. Urol Nefrol (Mosk) 1994;(6):5-9. View Abstract
Mercier J, Piot B, Gueguen P, et al. [The coral orbital floor. Its value in traumatology. The results of a multicenter study of 83 cases]. Rev Stomatol Chir Maxillofac. 1996;97(6):324-331. View Abstract
Schulz A, Hilgers RD, Niedermeier W. The effect of splinting of teeth in combination with reconstructive periodontal surgery in humans. Clin Oral Investig. 2000;4(2):98-105. View Abstract
Vuola J, Bohling T, Kinnunen J, et al. Natural coral as bone-defect-filling material. J Biomed Mater Res. 2000;51(1):117-122. View Abstract
Copyright © 2013 Natural Standard (www.naturalstandard.com)
The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
March 22, 2017