March 21, 2017

Xylometazoline nasal spray

What is xylometazoline nasal spray?

Xylometazoline (Natru-Vent®) works to temporarily improve nasal congestion. It opens up the nasal passages that are swollen due to allergies, colds, or infections to help you breathe easier.

NOTE:This drug is discontinued in the United States.

What should my health care professional know before I use xylometazoline?

They need to know if you have any of these conditions:

  • diabetes

  • glaucoma or family history of glaucoma

  • heart disease

  • high blood pressure

  • prostate problems

  • thyroid disease

How should I take this medicine?

Follow the directions on the bottle. Do not use xylometazoline more than 3 days in a row or use more frequently than directed unless instructed by your doctor. After blowing your nose and removing the cap from the bottle, spray this product once inside each nostril with your head upright while sniffing. Do not get it into your eyes. Spray the product into the air a few times before you use it for the first time (brand new bottle). Wash your hands after applying, wipe the nozzle, and replace the cap. Blow your nose 3—5 minutes after using. Do not share this product with others. Sharing can spread infection.

What if I miss a dose?

Xylometazoline is used to treat symptoms of nasal stuffiness. You may not need to take a dose every 8—10 hours. Do not take double or extra doses. Do not use for more than three days in a row.

What drug(s) may interact with xylometazoline?

  • antidepressants, especially drugs known as MAO Inhibitors (MAOIs)-phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®), selegiline (Eldepryl®)

  • caffeine

  • clonidine

  • decongestants

  • ephedra, ma huang

  • guarana

  • medicines for weight loss

  • thyroid supplements

Tell your prescriber or health care professional about all other medicines that you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also, tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking xylometazoline?

The solution of xylometazoline should be clear. Throw away any spray or solution that is discolored. If your nasal congestion gets worse, contact your doctor.

What side effects may I notice from using xylometazoline?

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • blurred vision

  • dizziness

  • headache

  • increase in runny or stuffy nose

  • nausea

  • nervousness

  • rapid heart beat

  • tiredness

  • trouble sleeping

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • nasal burning or dryness

  • nasal tingling or stinging

  • sneezing

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open. Store between 2 and 30 degrees C (36 and 86 degrees F). Keep container tightly closed. Solution should be protected from light. Throw away any unused medicine after the expiration date.


March 21, 2017


U.S. FDA-approved Package Insert