Vestronidase alfa injection

What is this medicine?

VESTRONIDASE ALFA (ves TRON i dase AL fa) is an enzyme replacement. It is used to treat the symptoms of Mucopolysaccharidosis type VII (MPS VII; Sly syndrome). This medicine is not a cure.

How should I use this medicine?

This medicine is for infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of the medicine in children. While this drug may be prescribed for children as young as newborns for selected conditions, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

• breathing problems

• low blood pressure

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

• diarrhea

• pain, redness, or irritation at site where injected

What may interact with this medicine?

Interactions have not been studied.

What if I miss a dose?

It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• an unusual or allergic reaction to vestronidase alfa, other medicines, foods, dyes, or preservatives

• pregnant or trying to get pregnant

• breast-feeding

What should I watch for while using this medicine?

This medicine can cause serious allergic reactions. To reduce your risk you may need to take medicine before treatment with this medicine. Take your medicine as directed.

Your condition will be monitored carefully while you are receiving this medicine.