Tofacitinib extended-release tablets
What is this medicine?
TOFACITINIB (TOE fa SYE it nib) is a medicine that works on the immune system. This medicine is used to treat rheumatoid arthritis and psoriatic arthritis.
How should I use this medicine?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
signs of infection - fever or chills, cough, sore throat, pain or trouble passing urine
signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
stomach pain or a sudden change in bowel habits
unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
What may interact with this medicine?
Do not take this medicine with any of the following medications:
This medicine may also interact with the following medications:
antiviral medicines for hepatitis, HIV or AIDS
azathioprine, cyclosporine, or other immunosuppressive drugs
biologic medicines such as abatacept, adalimumab, anakinra, certolizumab, etanercept, golimumab, infliximab, rituximab, secukinumab, tocilizumab, ustekinumab
certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, voriconazole
certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
supplements, such as St. John's wort
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Where should I keep my medicine?
Keep out of the reach of children.
Store between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
immune system problems
infection (especially a virus infection such as chickenpox, cold sores, or herpes)
low blood counts, like low white cell, platelet, or red cell counts
stomach or intestine problems
an unusual or allergic reaction to tofacitinib, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
What should I watch for while using this medicine?
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.
The tablet shell of this medicine does not dissolve. This is normal. The tablet shell may appear whole in the stool. This is not a cause for concern.
Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.
June 15, 2018