Tacrine
Tacrine Hydrochloride Oral capsule
What is this medicine?
TACRINE (TAK reen) is used to treat mild to moderate dementia caused by Alzheimer's disease.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
difficulty passing urine
heart disease, slow heartbeat
jaundice
liver disease
lung or breathing disease, like asthma
seizures
stomach or intestinal disease, ulcers or stomach bleeding
an unusual or allergic reaction to tacrine, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How should I use this medicine?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. It is best to take this medicine on an empty stomach, at least 1 hour before or 2 hours after meals. If this medicine upsets your stomach, you can take it with food. Take your doses at regular intervals. Do not take your medicine more often than directed. Continue to take your medicine even if you feel better. Do not stop taking except on the advice of your doctor or health care professional.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medicine?
atropine
benztropine
cimetidine
dicyclomine
donepezil
fluvoxamine
galantamine
glycopyrrolate
ipratropium
medicines for motion sickness like dimenhydrinate, meclizine, scopolamine
medicines that relax your muscles for surgery
NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
oxybutynin
propantheline
rivastigmine
theophylline
tolterodine
trihexyphenidyl
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Visit your doctor or health care professional for regular checks on your progress. Your doctor will need to regularly check your blood to monitor the effect of this medicine on your liver. Check with your doctor or health care professional if there is no improvement in your symptoms or if they get worse.
Avoid alcohol while you are taking this medicine. Alcohol may increase the risk of getting liver damage. Also try to avoid smoking. Smoking tobacco may lessen the effect of this medicine. Ask your doctor or health care professional for ways to help you stop smoking or drinking.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
changes in vision
dark yellow or brown urine
diarrhea, if it is severe or does not stop
dizziness, fainting spells, or falls
increase in frequency of passing urine, or incontinence
muscle pains
nervousness, agitation, or increased confusion
pain in the stomach or abdomen
slow heartbeat, or palpitations
sweating
uncontrollable movements
vomiting
yellowing of eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
diarrhea
dry mouth
indigestion
loss of appetite
nausea
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
Keep out of reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture. Throw away any unused medicine after the expiration date.
Updated:  
March 21, 2017
Sources:  
U.S. FDA-approved Package Insert