Natalizumab injection
Natalizumab injection
What is this medicine?
NATALIZUMAB (na ta LIZ you mab) is used to treat relapsing multiple sclerosis. This drug is not a cure. It is also used to treat Crohn's disease.
How should I use this medicine?
This medicine is for infusion into a vein. It is given by a health care professional in a hospital or clinic setting.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
breathing problems
changes in vision
chest pain
confusion
depressed mood
dizziness
feeling faint; lightheaded; falls
general ill feeling or flu-like symptoms
loss of memory
missed menstrual periods
muscle weakness
problems with balance, talking, or walking
signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
suicidal thoughts, mood changes
unusual bruising or bleeding
unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
headache
joint pain
muscle cramps
muscle pain
nausea, vomiting
pain, redness, or irritation at site where injected
tiredness
What may interact with this medicine?
Do not take this medicine with any of the following medications:
biologic medicines such as adalimumab, certolizumab, etanercept, golimumab, infliximab
This medicine may also interact with the following medications:
azathioprine
cyclosporine
interferons
6-mercaptopurine
methotrexate
other medicines that lower your chance of fighting an infection
steroid medicines like prednisone or cortisone
vaccines
What if I miss a dose?
It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.
Where should I keep my medicine?
This drug is given in a hospital or clinic and will not be stored at home.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
immune system problems
progressive multifocal leukoencephalopathy (PML)
an unusual or allergic reaction to natalizumab, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
What should I watch for while using this medicine?
Your condition will be monitored carefully while you are receiving this medicine. Visit your doctor for regular check ups. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.
Stay away from people who are sick. Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself.
In some patients, this medicine may cause a serious brain infection that may cause death. If you have any problems seeing, thinking, speaking, walking, or standing, tell your doctor right away. If you cannot reach your doctor, get urgent medical care.
Updated:  
June 26, 2020