Lopinavir; Ritonavir oral solution
What is this medicine?
LOPINAVIR; RITONAVIR (loe PIN a veer; ri TOE na veer) is two antiretroviral medicines in one tablet. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. It will not stop the spread of HIV to others.
How should I use this medicine?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with food. Use a specially marked spoon or container to measure the dose. Household spoons are not accurate. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your anti-HIV therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the HIV virus resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for infants as young as 14 days old for selected conditions, precautions do apply.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
fast, irregular heart rate
feeling faint or lightheaded, falls
nausea, vomiting, abdominal pain
red, hot, painful spot on leg
redness, blistering, peeling or loosening of the skin, including inside the mouth
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
increased hunger or thirst
unusually weak or tired
weight gain around waist, back, or thinning of face, arms, legs
What may interact with this medicine?
Do not take this medicine with any of the following medications:
certain medicines for cholesterol like lovastatin, simvastatin
certain medicines for hepatitis C like elbasvir; grazoprevir, boceprevir, simeprevir, dasabuvir; ombitasvir; paritaprevir; ritonavir
ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
red yeast rice
St. John's wort
This medicine may also interact with the following medications:
birth control pills
certain medicines for blood pressure like felodipine, nicardipine, nifedipine
certain medicines for cancer like vinblastine, vincristine, dasatinib, nilotinib, venetoclax
certain medicines for cholesterol like atorvastatin
certain medicines for erectile dysfunction like sildenafil, tadalafil, vardenafil
certain medicines for fungal infections like fluconazole, isavuconazonium, itraconazole, ketoconazole, posaconazole, voriconazole
certain medicines for irregular heart beat like amiodarone, bepridil, lidocaine, quinidine
certain medicines for seizures like carbamazepine, lamotrigine, phenobarbital, phenytoin, valproate
certain medicines that treat or prevent blood clots like warfarin
other medicines for HIV or AIDS
other medicines that prolong the QT interval (cause an abnormal heart rhythm)
steroid medicines like budesonide, dexamethasone, fluticasone, prednisone, triamcinolone
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Where should I keep my medicine?
Keep out of the reach of children.
Store in the refrigerator between 2 and 8 degrees C (36 and 46 degrees F). Throw away any unused medicine after the expiration date. If stored at room temperature, up to 25 degrees C (77 degrees F), you must throw the medicine away after 2 months.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
an unusual or allergic reaction to lopinavir, ritonavir, other medicines, castor oil, foods, dyes, or preservatives
pregnant or trying to get pregnant
What should I watch for while using this medicine?
Visit your doctor or health care professional for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.
HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV.
Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control. Women who can still have children must use a reliable form of barrier contraception, like a condom or diaphragm.
This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.
Some products may contain alcohol. Ask your pharmacist or healthcare provider if this medicine contains alcohol. Be sure to tell all healthcare providers you are taking this medicine. Certain medicines, like metronidazole and disulfiram, can cause an unpleasant reaction when taken with alcohol. The reaction includes flushing, headache, nausea, vomiting, sweating, and increased thirst. The reaction can last from 30 minutes to several hours.
July 17, 2018