Letermovir tablets

What is this medicine?

Letermovir (let er' moe vir) is an antiviral medicine. It is used to prevent infections caused by certain kinds of viruses.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue)

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

• cough

• diarrhea

• headache

• nausea, vomiting

• stomach pain

• swelling of the ankles, feet, hands

• tiredness

What may interact with this medicine?

Do not take this medicine with any of the following medications:

• bosentan

• certain medicines for HIV or AIDS like efavirenz, etravirine, nevirapine

• certain medicines for infection like nafcillin, rifabutin, rifampin

• certain medicines for seizures like carbamazepine, phenobarbital, phenytoin

• ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine

• modafinil

• pimozide

• St. John's Wort

• thioridazine

This medicine may also interact with the following medications:

• alfentanil

• amiodarone

• certain medicines for cholesterol like atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin

• certain medicines for diabetes, like glyburide, repaglinide, rosiglitazone

• certain medicines for stomach problems like omeprazole, pantoprazole

• certain medicines that treat or prevent blood clots like warfarin

• cyclosporine

• fentanyl

• midazolam

• quinidine

• sirolimus

• tacrolimus

• voriconazole

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• kidney disease

• liver disease

• an unusual or allergic reaction to letermovir other medicines, foods, dyes, or preservatives

• pregnant or trying to get pregnant

• breast-feeding

What should I watch for while using this medicine?

You may need blood work done while you are taking this medicine.

Your condition will be monitored carefully while you are receiving this medicine.