Natural Standard Bottom Line Monograph, Copyright © 2013 (www.naturalstandard.com). Commercial distribution prohibited. This monograph is intended for informational purposes only, and should not be interpreted as specific medical advice. You should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.
While some complementary and alternative techniques have been studied scientifically, high-quality data regarding safety, effectiveness, and mechanism of action are limited or controversial for most therapies. Whenever possible, it is recommended that practitioners be licensed by a recognized professional organization that adheres to clearly published standards. In addition, before starting a new technique or engaging a practitioner, it is recommended that patients speak with their primary healthcare provider(s). Potential benefits, risks (including financial costs), and alternatives should be carefully considered. The below monograph is designed to provide historical background and an overview of clinically-oriented research, and neither advocates for or against the use of a particular therapy.
Amaroli, auto-urine therapy, auto-urotherapy, Gomutra, Mutra Varga, Naramutra, Pergonal, shivambu, urea, urea therapy, uro-therapy, urotherapy.
Urine therapy refers to use of one's urine to maintain health, to prevent or cure sickness, to enhance beauty, or to promote meditation and spiritual enlightenment. Urine has been ingested, injected, or applied topically.
Urine therapy can be traced back as far as 5,000 years to early civilizations such as the Aztecs, ancient Egyptians, ancient Chinese, and Native Americans. It is believed that the origin of this practice comes from certain religious rites among Hindus, where it is called amaroli in tantric religious traditions. Medically, urine is referred to as "plasma ultrafiltrate." Advocates of urotherapy claim that this treatment is effective for dry skin, cancer, and numerous other diseases and disorders.
Research has revealed components of urine such as urea, hormones, and enzymes. Many of these components have been commercially isolated and marketed. For example, urokinase (an enzyme that promotes the break-up of blood clots) is used in drug form and sold as a thrombolytic for unblocking coronary arteries. Furthermore, luteinizing hormone and follicle stimulating hormone are the active components in Pergonal, a drug used to stimulate fertility in women. Urea is used in several creams to promote healthy skin.
Current researchers are investigating urotherapy in the treatment of AIDS and cancer.
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
There is insufficient evidence from clinical studies to support the use of urine or urea in the treatment of liver cancer. Additional studies are needed to make a firm recommendation.
An oral urea preparation (carbamine) has been used in peptic ulcer therapy. However, there is insufficient evidence from clinical studies to support the use of urine or urea in the treatment of peptic ulcers. Additional study is needed to draw any firm conclusions.
Sickle cell anemia
Some evidence suggests that urea may help prevent and treat sickle cell crises in addition to helping eliminate complications. However, there is no definitive evidence from clinical studies to support the use of urine or urea in the treatment of sickle cell anemia. Additional study is needed in this area.
*Key to grades:A: Strong scientific evidence for this use; B: Good scientific evidence for this use; C: Unclear scientific evidence for this use; D: Fair scientific evidence against this use (it may not work); F: Strong scientific evidence against this use (it likely does not work).
The below uses are based on tradition or scientific theories. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious and should be evaluated by a qualified health care professional.
Abdominal distention, abdominal pain, aging, AIDS, allergies, anemia, animal bites, anthelmintic (expels worms), antibiotic, antidote to poisons, anti-fungal, asthma, arteriosclerosis, baldness, bladder disorders, blood disorders, burns, chicken pox, cognitive performance, colic, common cold, constipation, coronary artery disease, cough, digestive disorders, dry skin, earache, eczema, edema, endocrine disorders, eye diseases, fatigue, fever, flatulence, flu, glomerulonephritis (inflammation of the kidney), gonarthritis, heart disease, heart attack, hematuria (sickle cell crisis), hypertension (high blood pressure), infertility, insomnia, jaundice, leprosy, liver disorders, migraine, mouth infections, painful urination, pruritus (itching), psoriasis, pulmonary embolism, Raynaud's phenomenon, scabies, sexual performance, skin ailments, sleep, splenomegaly (enlarged spleen), tonic, toothaches, tuberculosis, tumors, urinary tract infections, urticaria ("hives"), wound healing.
The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.
Adults (18 years and older):
There is no proven safe of effective dose. Fresh urine from midstream of the first urine flow of the day has been used. Urine has been taken in small amounts (such as a few drops in some water and increased to 20 drops) placed under the tongue morning and night over the course of three days. No food is advised at least half an hour after drinking. Aged, boiled or fresh urine has been used for washing or massaging.
Children (younger than 18 years):
There is no proven safe of effective dose for urine therapy, and use in children is not recommended.
Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.
Avoid in individuals with known allergies or hypersensitivities to urine or any of its metabolites.
Side Effects and Warnings
Common adverse effects of urine therapy may include diarrhea, itch, pain, fatigue, soreness of the shoulder, and fever. These side effects may last three to seven days or up to six months. Aged urine may be caustic on the skin.
Urine therapy may be unsafe when used in children, individuals taking medications that are excreted in the urine as unchanged or active metabolites, individuals with gastrointestinal problems, or pregnant women. Avoid in patients who have urinary tract or kidney infection because the urine will contain bacteria.
The Damar Tantra, an ancient Sanskrit work, says that fresh urine will cause muscle wasting when left on the skin if the urine has not been boiled down to one fourth its volume (vs. 49 of the Shivambu Kalpa Vidhi in the Damar Tantra).
Pregnancy and Breastfeeding
Avoid during pregnancy and breastfeeding because urine contains excreted hormones.
Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.
Interactions with Drugs
Many drugs are excreted in the urine as unchanged or active metabolites. Urine consumption may increase the amount of these drugs. For example, melatonin in the urine may interact with antidepressants or antipsychotics. Melatonin may also interact with sedative/hypnotic agents and may increase the amount of drowsiness caused by some drugs. Consult with a qualified healthcare professional, including a pharmacist, before combining therapies.
Interactions with Herbs and Dietary Supplements
Many drugs are excreted in the urine as unchanged or active metabolites. Urine consumption may increase the amount of these drugs. For example, melatonin in the urine may interact with herbs and supplements with antidepressant or antipsychotic effects. Melatonin may also interact with sedative/hypnotic agents and may increase the amount of drowsiness caused by some herbs and supplements. Consult with a qualified healthcare professional, including a pharmacist, before combining therapies.
This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).
Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Christopher L, Fitzgerald O. A clinical trial of an oral urea preparation (Carbamine) in peptic ulcer therapy. Ir.J Med Sci 1968;7(6):243-253. View Abstract
Collen D, Lijnen HR. New approaches to thrombolytic therapy. Arteriosclerosis 1984;4(6):579-585. View Abstract
Danopoulos ED, Danopoulos IE. Letter: Urea treatment of skin malignancies. Lancet 6-8-1974;1(7867):1161. View Abstract
Danopoulos ED, Danopoulou IE. Eleven years experience of oral urea treatment in liver malignancies. Clin Oncol. 1981;7(4):281-289. View Abstract
Danopoulos ED, Danopoulou IE. Letter: Regression of liver cancer with oral urea. Lancet 1-26-1974;1(7848):132. View Abstract
Eldor J. Urotherapy for patients with cancer. Med Hypotheses 1997;48(4):309-315. View Abstract
Gail M, Beach J, Dark A, et al. A double-blind randomized trial of low-dose oral urea to prevent sickle cell crises. J Chronic.Dis. 1982;35(2):151-161. View Abstract
Gupta RK, Huth JF, Korn EL, Morton DL. Prognostic significance of urinary antigen analysis by enzyme-linked immunosorbent assay in melanoma patients. Diagn.Immunol. 1983;1(4):303-309. View Abstract
Hooper TL, Rahman M, Magell J. Oral urea in the treatment of colo-rectal liver metastases. Clin Oncol. 1984;10(4):341-344. View Abstract
Krueger JM, Pappenheimer JR, Karnovsky ML. Sleep-promoting effects of muramyl peptides. Proc Natl.Acad Sci U.S.A 1982;79(19):6102-6106. View Abstract
Mills MH, Faunce TA. Melatonin supplementation from early morning auto-urine drinking. Med Hypotheses 1991;36(3):195-199. View Abstract
Padzik H, Paszko Z, Pronaszko A. Purification of pituitary gonadotropins from the urine of women after menopause and trials of separating luteinizing from follicle stimulating hormone. Arch Immunol.Ther Exp (Warsz.) 1969;17(5):655-673. View Abstract
Pariser S, Katz A. Treatment of sickle cell trait hematuria with oral urea. J Urol 1994;151(2):401-403. View Abstract
Sevcik J, Masek K. The interaction of immunomodulatory muramyl dipeptide with peripheral 5-HT receptors: overview of the current state. Int J Immunopharmacol. 1999;21(3):227-232. View Abstract
Treatment of sickle cell crisis with urea in invert sugar. A controlled trial. Cooperative urea trials group. JAMA 5-27-1974;228(9):1125-1128. View Abstract
Copyright © 2013 Natural Standard (www.naturalstandard.com)
The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
March 22, 2017